曲美他嗪对急性非ST段抬高心肌梗死患者左心功能的影响  

Effects of Trimetazidine Therapy on Short-term Left Ventricular Functions in Patients with NSTEMI Undergoing Percutaneous Coronary Intervention

作　　者：李远征[1] 王立中[1] 董鹏[1] 刘芳[1] 姜阳[1] 李银花[1] Li Yuan-zheng;Wang Li-zhong;Dong Peng;Liu Fang;Jiang Yang;Li Yin-hua

机构地区：[1]航空总医院心内科,北京100012

出　　处：《中国医药导刊》2016年第7期695-696,698,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨曲美他嗪对行经皮冠状动脉介入治疗(PCI)的急性非ST段抬高心肌梗死(NSTEMI)患者短期的左心功能和血浆N-末端脑钠肽前体(NT-pro BNP)的影响。方法:PCI治疗的NSTEMI患者50例完全随机分为对照组和曲美他嗪组,各25例。两组均给予常规冠心病二级预防药物,曲美他嗪组再于PCI术前给予曲美他嗪60mg顿服,PCI术后20mg/次,3次/日,口服3个月。测定并比较两组患者在PCI术前、术后1周、3个月时血浆NT-pro BNP、左心室舒张末期容积(LVEDV)、左心室射血分数(LVEF)和心肌做功指数(MPI)。结果:3个月时,两组NT-pro BNP均较PCI术前明显降低(P<均0.01),曲美他嗪组降低的幅度极明显大于照组(P<0.01)。两组LVEDV均较PCI前有降低,曲美他嗪组降低的幅度明显大于照组(P<0.05)。曲美他嗪组LVEF较对照组和PCI术前均显著提高(P<0.05);曲美他嗪组MPI较对照组显著降低(P<0.01)。结论:急性NSTEMI患者PCI术前和术后短期给予曲美他嗪治疗能够降低NT-pro BNP水平,改善左心功能。Objective: To explore the effects of therapy with oral trimetazidine (TMZ) applied before and after percutaneouscoronary interventions (PCI) on short-term left ventricular functions and plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP)levels in patients with non-ST segment elevation myocardial infarction (NSTEMI) undergoing PCI. Methods: 50 cases of NSTEMI wererandomly divided into control group and trimetazidine group Sibutramine PCI cases, 25 cases in each. Two groups were given conventionalsecondary prevention of coronary heart disease drug, trimetazidine group again in front of the PCI given trimetazidine trimetazidine 60meal service, after PCI 20mg, 3 times / day, oral three month. To determine and compare the two groups of patients after PCI preoperativeand postoperative 1 week, 3 months of plasma NT proBNP, left ventricular diastolic end diastolic volume (LVEDV) and left ventricularejection fraction (LVEF) and Tei index (MPI) shot.Results: 3 months, two groups of NT proBNP were compared with those before PCIdecreased significantly (P<0.01), trimetazidine trimetazidine group decreased significantly greater than controls (P< 0.01). Two groups ofLVEDV were lower than PCI before the lower Sibutramine trimetazidine group decreased more than control group (P<0.05). Trimetazidinetrimetazidine group LVEF compared with the control group and before PCI were significantly increased (P<0.05); trimetazidine groupMPI compared with the control group decreased significantly (P<0.01).Conclusion: Trimetazidine therapy commencing prior to PCI andcontinued after PCI in patients with NSTEMI is able to decrease NT-proBNP levels and improve short-term left ventricular function.

关 键 词：曲美他嗪 急性非ST段抬高心肌梗死 血浆N-末端脑钠肽前体 左心室功能 

分 类 号：R542.22[医药卫生—心血管疾病]