1,2,3-三氮唑桥连维生素D_2类化合物的合成  

Synthesis of 1,2,3-triazole bridge-connected Vitamin D_2 compounds

作　　者：潘峰[1] 方志杰[1] PAN Feng;FANG Zhi-jie*(School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China)

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《化学研究与应用》2016年第8期1109-1113,共5页Chemical Research and Application

基　　金：江苏省产学研联合创新资金前瞻性联合研究项目(BY2013004-02)资助;南京理工大学研究生科研创新计划资助项目

摘　　要：以维生素D2和对甲苯磺酰氯为原料,经磺酰化反应保护维生素D2羟基,再与叠氮化钠发生亲核取代得到3-叠氮维生素D2,后者与芳香炔、脂肪炔发生Click反应,合成6种具有1,2,3-三氮唑结构的新型维生素D2衍生物。目标化合物的结构经1H-NMR、13C-NMR、ESI-MS确认。Vitamin D2 was condensed with p-toluene sulfonyl chloride to afford hydroxyl protected vitamin D2 by sulfonylation reaction.Six novel vitamin D2 derivatives were prepared via Click reaction of aromatic alkyne with 3-azide vitamin D2 ,which was synthesizedfrom hydroxyl protected vitamin D2 and sodium azide. These structure of the products were confirmed by 1 H-NMR,13 C-NMR,ESI-MS.

关 键 词：维生素D2 1 2 3-三氮唑 CLICK 

分 类 号：O626.26[理学—有机化学]