聚对二氧环己酮在不同介质中的体外降解研究  

In vitro hydrolytic degradation of poly( para-dioxanone)with different mediums

作　　者：李银涛[1] 贾瑞虹[1] 白威[2] 张志萍[2] LI Yin-tao;JIA Rui-hong;BAI Wei;ZHANG Zhi-ping(Department of Pharmacy Changzhi Medical College,Changzhi 046000,China;Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China)

机构地区：[1]长治医学院药学系,山西长治046000 [2]中国科学院成都有机化学研究所,四川成都610041

出　　处：《化学研究与应用》2016年第8期1165-1168,共4页Chemical Research and Application

基　　金：中国科学院"西部之光"人才培养计划项目

摘　　要：研究了聚对二氧环己酮(PPDO)在蒸馏水(p H=6.50),生理盐水(p H=4.50),PBS缓冲溶液(p H=7.44)中,37℃条件下降解过程中的质量损失、吸水率、特性粘度以及环境的p H值变化情况,以及其力学性能的变化。研究发现PPDO在蒸馏水和生理盐水中降解行为明显加速。The in vitro degradation of Poly(para-dioxanone)with different mediums was studied by the changes of weight retention,water absorption,viscosity,pH value and mechanicalproperties of PPDO samples were examined in distilled water (H2 O) (pH6. 50)、normal saline(NS)(pH 4. 50)and phosphate buffered saline(PBS)(pH 7. 44)at 37℃ for 4 weeks. The results suggestedthat the PPDO samples in H2 O and NS exhibited faster degradation rate in vitro degradation.

关 键 词：聚对二氧环己酮 体外降解 蒸馏水 生理盐水 缓冲溶液 

分 类 号：O633.1[理学—高分子化学]