早期阿托伐他汀联合依折麦布治疗急性冠脉综合征临床疗效  

Early Joint Atorvastatin According to Fold the Mab Clinical Efficacy in the Treatment of Acute Coronary Syndrome

作　　者：朱梅生[1] 周晓辉[1] ZHU Mei-sheng;ZHOU Xiao-hui(The First Affiliated Hospital of Xinjiang Medical University Urumqi, Wulumuqi Xinjiang 830054, China)

机构地区：[1]新疆医科大学第一附属医院干部病房内一科,新疆乌鲁木齐830054

出　　处：《药品评价》2016年第14期48-50,共3页Drug Evaluation

摘　　要：目的:分析给予急性冠脉综合征患者进行早期阿托伐他汀联合依折麦布临床效果。方法:从2013年3月—2015年11月我院共收治急性冠脉综合征患者98例,随机分为2组,实验组49例,给予患者进行阿托伐他汀联合依折麦布,对照组49例,给予患者进行阿托伐他汀治疗。结果:实验组患者在治疗4周后,和治疗之前相比较,患者体内TC、TG、LDL-C都显著下降,两者具有差异性(P<0.05),实验组患者体内TC、LDL-C水平比对照组显著下降(P<0.05),而ALT与CK水平无显著升高,无差异性(P>0.05);实验组患者再发心绞痛与心肌梗死例数小于对照组,两者具有差异性(P<0.05),而实验组死亡例数以及ATL和CK与对照组相比,两者无差异性(P>0.05)。结论:给予急性冠脉综合征患者进行早期阿托伐他汀联合依折麦布,可提高患者生活质量,应用价值极高,值得在临床上推广使用。Objective: To analyze the acute coronary syndrome patients given early atorvastatin combined with ezetimibe clinical effect. Methods: Inour hospital there were 98 patients with acute coronary syndrome, randomly divided into two groups, the experimental group of 49 patients, patientsgiven atorvastatin ezetimibe combined with the control group, 49 cases, patients were given atorvastatin statin therapy. Results: The patients inthe treatment after four weeks, compared to the prior and treatment, patient TC, TG, LDL-C were significantly decreased, both having a difference(P<0.05), the body of the patient in the experimental group TC, LDL-C was significantly lower than that in the control group (P<0.05), while ALT andCK levels were not significantly increased, no significant differences (P>0.05). The experimental group of patients with recurrent angina, myocardialinfarction, the number of cases is less than the control group, both have differences (P<0.05), while the experimental group, the number of deaths aswell as ATL and CK compared with the control group, there was no difference (P>0.05). Conclusions: Patients with acute coronary syndrome givenearly atorvastatin combined with ezetimibe can reduce LDL-C levels in patients and reduce angina and other adverse reactions.

关 键 词：急性冠脉综合征 阿托伐他汀 依折麦布 生活质量 

分 类 号：R541.4[医药卫生—心血管疾病]