67例哮喘患者变应原检测及SIgE与IL-2血清蛋白表达相关性分析  

Detection of allergens in 67 patients with asthma and analysis of the correlation between SIgE and IL-2 expression in serum protein

作　　者：杨清[1] 姜孝芳[2] 韩继红[1] 马冬均 高丽[2] Yang Qing;Han Jihong;Jiang Xiaofang;Ma Dongjun;Gao Li(The Sixth Affiliated Hospital of Xinjiang Medical University 830002;Children's Hospital in Urumqi 830054;Xinjiang Medical University 830091)

机构地区：[1]新疆医科大学第六附属医院,830002 [2]乌鲁木齐市儿童医院,830054 [3]新疆医科大学,830091

出　　处：《中国社区医师》2016年第23期151-152,154,共3页Chinese Community Doctors

基　　金：新疆维吾尔自治区自然科学基金医学联合基金(2014211C134);新疆医科大学科研创新基金(XJC20121430)~~

摘　　要：目的:探讨成人支气管哮喘患者变应原分布特点及SIgE与IL-2血清蛋白表达的相关性。方法:收治哮喘患者67例和同期健康体检者60例,进行变应原检测,同时检测IL-2、SIgE血清蛋白表达。结果:67例哮喘患者系统变应原过筛总阳性率94%,其中吸入变应原阳性率69.4%,食物变应原阳性率30.6%,艾蒿和树木组合(柳树/杨树/榆树)是最主要和最强烈的变应原,吸入变应原的致敏性较食物变应原强。哮喘组IL-2、SIgE血清蛋白表达与对照比较,差异有统计学意义(P<0.05),SIgE与IL-2血清蛋白呈负相关。结论:在过敏因素中,吸入性变应原是诱发支气管哮喘的主要因素,而艾蒿、树木组合(柳树/杨树/榆树)等又是吸入变应原中的主要变应原,特异性变应原能促进SIgE的分泌,IL-2可能抑制SIgE。Objective:To investigate the allergen distribution characteristics of adult patients with bronchial asthma and the correlation between the expression of SIgE and IL-2 in serum.Methods:67 patients with asthma and 60 cases received healthy physical examination in the same period were selected.Allergens were detected in patients.The expression of IL-2 and SIgE in serum were detected simultaneously.Results:The total positive rate of system allergen was 94% in 67 patients with asthma,the positive rate of inhaled allergens was 69.4% ,and the positive rate of food allergens was 30.6% .Mugwort and tree combination(willow/poplar/elm) were the most important and the most potent allergens.The sensitization of inhaled allergens was stronger than that of food allergens.The expression of IL-2 and SIgE in the asthma group were different from that in the control group(P<0.05),and SIgE and IL-2 serum protein was negatively correlated.Conclusion:Among the allergic factors,inhaled allergens are the main factors to induce bronchial asthma.The mugwort and tree combination(willow/poplar/elm)are the major allergen of inhalation allergen,and specific allergens can promote the secretion of SIgE,IL-2 may inhibit SIgE.

关 键 词：变应原 哮喘 IL-2 SIGE 

分 类 号：R562.25[医药卫生—呼吸系统]