α_1受体阻滞剂在输尿管镜碎石术后应用的临床研究  

Clinical Research of the application of Alpha-1 receptor antagonist after ureteroscopic ureterolithotomy

作　　者：林毅枢 薛建[1] Lin Yishu;Xue Jian(Department of Urology,Beijing Haidian Hospital 100080)

机构地区：[1]北京市海淀医院泌尿外科,100080

出　　处：《中国社区医师》2016年第13期11-13,15,共4页Chinese Community Doctors

摘　　要：目的:评价α_1受体阻滞剂在经尿道输尿管镜碎石术治疗单侧输尿管结石中的临床作用。方法:收治单侧输尿管结石患者110例,行经尿道输尿管镜气压弹道碎石术,术后均顺利留置双J管。术后随机平分为两组。常规组接受常规治疗,联合组在常规治疗的同时给予特拉唑嗪治疗,记录相关指标。结果:常规组结石残留碎片排出率87.27%,低于联合组的96.36%;结石残留碎片排出时间(7.01±3.06)d,低于联合组的(4.87±2.34)d。联合组对视觉疼痛模拟评分(VAS)、国际前列腺症状评分(IPSS)、生活质量指数评分(QOL)以及肉眼血尿情况均优于常规组(P<0.05)。结论:α_1受体阻滞剂对经尿道输尿管镜碎石术后结石残留碎片的排出有明确的作用,也可改善因双J管引起的相关临床症状。Objective:To evaluate the clinical effect of the application of alpha-1 receptor antagonist after ureteroscopicureterolithotomy treating unilateral ureteral calculus.Methods:110 patients with unilateral ureteral calculus were selected,allpatients underwent transurethral pneumatic lithotripsy and all of them were remained double-J-stent after operation successfully.The patients were randomly divided into the two groups after surgery.The routine group was given conventional therapy,while theunite group was not only given conventional therapy,but also was given alpha-1 receptor antagonist,we recorded related indicators.Results:Compared with the routine group,the unite group was associated with higher the expulsion rate(96.36% vs 87.27% )andshorter the expulsion time[(4.87±2.34)d vs(7.01 ±3.06)d].The unite group displayed obvious advantage in visual analogue painscale(VAS),international prostate symptom score(IPSS),quality of life(QOL)and gross hematuria compared with the routine group.Conclusion:Alpha-1 receptor antagonist can promote clearly the expulsion of stone lithiasis's residual fragment,and also alleviatethe clinical symptom related with double-J-stent.

关 键 词：Α1受体阻滞剂 输尿管镜 治疗 

分 类 号：R699.4[医药卫生—泌尿科学]