肝血管平滑肌脂肪瘤的形态学变异和免疫组织化学特征  

Morphological variations and immunohistochemical features of hepatic angiomyolipoma

作　　者：袁倩[1] Yuan Qian(Department of Pathology,the Eighth People's Hospital of Qingdao City 266100)

机构地区：[1]青岛市第八人民医院病理科,266100

出　　处：《中国社区医师》2016年第14期127-128,共2页Chinese Community Doctors

摘　　要：目的:探讨肝脏血管平滑肌脂肪瘤(AML)的病理学、免疫组织化学特征及诊断要点。方法:收治肝脏AML切除手术患者50例,针对免疫组织化学中的标志物表达展开系统检测。结果:该肿瘤主要由脂肪、厚壁血管和平滑肌细胞构成,按照肿瘤组织的成分比可以分成经典型14例,肌细胞为主29例,脂肪细胞为主4例,血管瘤型3例;另外,肌细胞呈现出不同形态变异。经过免疫组织化学处理,瘤细胞呈现出HMB45(100%)、CD117(40例,80%)以及SMA(100%)阳性反应。结论:在临床中,肝脏AML的形态学变异相对较大,很容易出现误诊、漏诊现象,HMB45呈现阳性有比较好的诊断价值,另外CD117能够作为比较好的AML诊断辅助性标记物。Objective:To explore the pathologic and immunohistochemical features and diagnostic points of hepaticangiomyolipoma(AML).Methods:50 cases of hepatic AML with resection were selected.We carried out the systematic detection forthe expression of markers in the immunohistochemistry.Results:The tumor was mainly composed of fat,thick walled blood vesselsand smooth muscle cells.According to the composition of the tumor tissue,they can be divided into 14 cases of classic type,29cases of muscle cells,4 cases of fat cells,and 3 cases of hemangioma type.In addition,the muscle cells showed differentmorphological variation.After immunohistochemical treatment,tumor cells showed positive reaction in HMB45(100%),CD117(40cases,80% ) and SMA(100% ).Conclusion:In clinical practice,the morphological variation of hepatic AML was relatively large.Itwas very easy to be misdiagnosed.Positive HMB45 had better diagnostic value.In addition,CD117 can be used as a good markerfor the diagnosis of AML.

关 键 词：AML 形态学变异 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]