免疫抑制剂治疗激素耐药性肾病综合征的临床观察  

Clinical observation of immunosuppressive agents in the treatment of steroid-resistant nephrotic syndrome

作　　者：徐金霞 Xu Jinxia(The Central Hospital of Xinyang City,Henan Province 464000)

机构地区：[1]河南省信阳市中心医院,464000

出　　处：《中国社区医师》2016年第2期63-64,共2页Chinese Community Doctors

摘　　要：目的:探讨免疫抑制剂治疗激素耐药性肾病综合征的临床效果。方法:收治激素耐药性肾病综合征患者60例,随机分成两组。对照组给予强的松治疗,观察组在对照组基础上加用环磷酰胺治疗,比较两组临床疗效。结果:两组血浆蛋白、24 h尿蛋白定量治疗前、治疗后比较,差异具有统计学意义(P<0.05)。观察组血浆蛋白、24 h尿蛋白定量治疗后与对照组比较,差异具有统计学意义(P<0.05)。观察组总有效率90.0%,显著高于对照组(P<0.05)。结论:免疫抑制剂治疗激素耐药性肾病综合征效果显著。Objective:To investigate the clinical effect of immunosuppressive agents in the treatment of steroid resistant nephrotic syndrome.Methods:60 cases of patients with steroid resistant nephrotic syndrome were divided into two groups randomly.The control group was treated with prednisone,the observation group was treated with cyclophosphamide based on the control group,the clinical effect of the two groups was compared.Results:There were significant differences of plasma protein and urine protein of 24 h before and after treatment between the two groups(P<0.05).There were significant differences of plasma protein and urine protein of 24 h after treatment between the two groups(P<0.05).The total effective rate of the observation group was 90%,which was significantly higher than that of the control group(P<0.05).Conclusion:Immunosuppressive agents in the treatment of steroid-resistant nephrotic syndrome had distinct clinical effect.

关 键 词：免疫抑制剂 激素耐药性肾病综合征 临床疗效 

分 类 号：R692[医药卫生—泌尿科学]