2型糖尿病发生糖尿病肾病的相关危险因素分析  

Analysis of related risk factors of diabetic nephropathy in type 2 diabetes mellitus

作　　者：王明铭[1] 陈海霞[1] 张东霞[1] 郭更新[1] 刘爱翔[1] Wang Mingming;Chen Haixia;Zhang Dongxia;Guo Gengxin;Liu Aixiang(Nephrology Department,the People's Hospital of Xingtai City,Hebei Province 054000)

机构地区：[1]河北省邢台市人民医院肾内科,054000

出　　处：《中国社区医师》2016年第7期41-42,共2页Chinese Community Doctors

基　　金：邢台市科技支撑项目(2014ZC059)~~

摘　　要：目的:探讨2型糖尿病(T2DM)患者发生糖尿病肾病(DN)的相关影响因素。方法:收治T2DM患者270例,按尿蛋白排泄率(UAER)分为DN组和2型糖尿病组(DM组),比较两组空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)及总胆固醇(TC)、尿酸(UA)等指标。结果:DN组年龄、病程、BMI、SBP、DBP、FPG、HDL-C、TG、UA、Hb A_(1c)水平均高于DM组(P<0.05);多因素回归分析表明,病程、Hb A_(1c)、BMI、SBP、UA、FPG与DN的发生存在密切相关性(P<0.05)。结论:糖尿病病程、Hb A_(1c)、BMI、SBP、UA、FPG与DN的发生、发展密切相关,临床防治DN过程中应注意对危险因素的干预。Objective:To explore the related risk factors of diabetic nephropathy in type 2 diabetes mellitus.Methods:270 patientswith T2DM were selected.According to urinary protein excretion rate(UAER),they were divided into the DN group and the type 2diabetes group(DM group).We compared fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),low density lipoproteincholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG) and total cholesterol(TC),uric acid (UA) andother indicators of two groups.Results:In the DN group,age,course of disease,BMI,SBP,DBP,FPG,HDL-C,TG,UA,HbA1c levelswere higher than those in the DM group(P<0.05).Multivariate regression analysis showed that the course of disease,HbA1c,BMI,SBP,UA,FPG was closely correlated with the occurrence of DN(P<0.05).Conclusion:The course of diabetes,HbA1c,BMI,SBP,UA,FPG were closely related to the occurrence and development of DN.We should pay attention to the intervention of the risk factorsin the process of the clinical prevention and treatment of DN.

关 键 词：糖尿病 糖尿病肾病 危险因素 

分 类 号：R587.2[医药卫生—内分泌]