比索洛尔对左室射血分数保留的心力衰竭患者嗜铬粒蛋白A及心功能的影响  

The effects of bisoprolol on chromaffin grain protein A and cardiac function of heart failure patients with preserved left ventricular ejection fraction

作　　者：甄宇治[1] 邓彦东[2] 段立楠[1] 战吟戈 刘超[1] 刘坤申[1] ZHEN Yu-zhi;DENG Yan-dong;DUAN Li-nan;ZHAN Yin-ge;LIU Chao;LIU Kun-shen(Department of Cardiology, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China.)

机构地区：[1]河北医科大学第一医院心血管内科,石家庄050031 [2]河北医科大学第一医院超声科,石家庄050031

出　　处：《中国循证心血管医学杂志》2016年第8期919-921,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：河北省卫生厅指令性课题(20130278)

摘　　要：目的观察比索洛尔对左室射血分数保留的心力衰竭（HFpEF）患者嗜铬粒蛋白A（CgA）的影响，探讨CgA在HFpEF患者中的价值及比索洛尔的治疗效果。方法选取2014年1月~2015年12月于河北医科大学第一医院心血管内科住院并诊断为左室射血分数保留的心力衰竭患者66例，随机分为治疗组和对照组，每组各33例，治疗组给予比索洛尔加标准化治疗，对照组仅给予标准化治疗。2周后检测两组患者CgA水平、监测超声心动图变化。结果两组患者治疗前CgA、左室射血分数（LVEF）、左室舒张末期内径（LVEDD）、左室收缩末内经（LVESD）、E峰、A峰、E/A、左室等容舒张时间（IVRT）指标差异无统计学意义（P＞0.05）。治疗后，以上观察指标治疗组的改善情况均优于对照组（P＜0.05）；治疗组总有效率优于对照组（87.87%vs.63.63%，P＜0.05）。结论比索洛尔治疗HFpEF患者效果显著，CgA为HFpEF患者的病情判断及预后提供了一定的临床价值。Objective To investigate the effects of bisoprolol on chromaffin granule protein A (CgA) in heart failure patients with preserved left ventricular ejection fraction (HFpEF), and to explore the role of CgA in HFpEF patients and the treatment effect of bisoprolol. Methods 66 chronic heart failure patients were randomly divided into treatment group and control group (33 patients in each group). Treatment group was given bisoprolol and standardized treatment, the control group was only given standardized treatment. CgA level and change of echocardiography were measured two weeks after treatment in two groups. Results There is no difference as to CgA level, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), E peak, A peak, E/A and left ventricular isovolumic relaxation time (IVRT) between two groups before treatment (P>0.05). After treatment, all the indexes above in treatment group were improved better than control group (P<0.05). The total effective rate in treatment group was higher than control group (87.87% vs. 63.63%, P<0.05). Conclusion The effect of bisoprolol on HFpEF patients is remarkable. CgA is useful for condition judgment and prognosis of HFpEF patients.

关 键 词：比索洛尔 心力衰竭 嗜铬粒蛋白A 

分 类 号：R541.61[医药卫生—心血管疾病]