钯催化氧气氧化的烯烃的分子间去氢胺卤化反应来构建溴代的烯胺类化合物研究报告  

Palladium-Catalyzed Intermolecular Dehydrogenative Aminohalogenation of Alkenes Under Molecular Oxygen:An Approach to Brominated Enamines

作　　者：江焕峰[1] 姬小趁[1] 黄华文[1] 伍婉卿 Jiang Huanfeng;Ji Xiaochen;Huang Huawen;Wu Wanqing(South China University of Technology)

机构地区：[1]华南理工大学

出　　处：《科技资讯》2016年第21期181-181,共1页Science & Technology Information

摘　　要：我们发展了一种新颖、高效的钯催化氧气氧化的烯烃的去氢胺卤化反应。它提供了一种非常有价值的合成手段来构建一系列的溴代烯胺类化合物,反应条件比较温和,并且具有非常好的立体选择性和官能团的耐受性。溴代烯胺类产物可以进一步发生多样化的转化过程,因此,这个构建此类物质的方法具有非常重要的实际应用价值。A novel and efficient palladium-catalyzed dehydrogenative aminohalogenation of alkenes with molecular oxygen as the sole oxidant has been developed. This protocol provides a valuable synthetic tool for the assembly of a wide range of brominated enamines under mild conditions, with unprecedented stereoselectivity and exceptional functional group tolerance.This attractive route for the synthesis of brominated enamines is of great significance due to the products’ versatile reactivity for further transformations.This work was published in J. Am. Chem. Soc. 2013, 135, 5286.

关 键 词：氧气 钯催化 卤代烯胺 

分 类 号：TQ616.8[化学工程—精细化工]