重金属铅诱发机体氧化应激效应的研究进展  

Current Perspectives on Lead-induced Oxidative Stress

作　　者：张浩[1] 刘汝涛[2] 魏云波[1] ZHANG Hao;LIU Rutao;WEI Yunbo(Key laboratoryof Immunology for Environment and Health, Shandong Analysis and Test Center, Jinan 250014;School of Environmental Science and Engineering, Shandong University, Jinan 250014)

机构地区：[1]山东省分析测试中心,山东省科学院环境与健康免疫重点实验室,济南250014 [2]山东大学,环境科学与工程学院,济南250014

出　　处：《科学与管理》2016年第5期49-57,共9页Science and Management

基　　金：山东省自然科学基金-山东省科学院联合基金项目(ZR2016YL013)

摘　　要：尽管各国政府已经采取多项措施限制和减少铅的使用,铅污染引发的健康问题依旧非常突出,仍是当前社会高度关注的环境污染与健康问题之一。研究表明,氧化应激是几乎所有疾病发生的诱因,而且铅类污染物对生命体的危害与氧化应激效应密切相关。铅暴露使机体产生过量的活性氧物质导致体内氧化还原平衡态被打破,造成蛋白质、核酸、脂类等生物大分子的氧化损伤,从而导致细胞凋亡或坏死和组织器官代谢紊乱,引发机体病变甚至癌症的发生。因此,有必要从生物大分子、细胞和实验动物三个层面系统综述铅暴露诱发机体氧化损伤的作用机理,阐述重金属铅诱发机体氧化应激效应的研究进展。Lead still possesses great threats to human health owing to its widespread distribution in the environmentcaused by human activities, although various actions have been taken to cut down the use and distribution of lead by thegovernments.Abundant evidence has indicated oxidative stress is a trigger of many varied diseases, which has still been oneof the biggest concerns on environmental pollution and health. Multiple studies have shown that lead toxicity is related tooxidative stress because it generates reactive oxygen species (ROS), interferes with antioxidant enzyme activities, and breaksthe balance of the pro-oxidant/antioxidant defense system, resulting in oxidative damage of proteins, nucleic acids andlipid compounds, cell apoptosis and necrosis, and metabolic disorders of tissues and organs of humans, and causes harmfuldiseases or cancers. Therefore, it is of great importance to review mechanisms of oxidative damage caused by lead combinedat the molecular, cellular and organismal levels to understand harmful effects of lead exposure to human health.

关 键 词：重金属铅 氧化应激 毒性效应 

分 类 号：Q8[生物学]