基于数据挖掘的古代通便丸剂用药规律研究  

Study on Medication Laws of Ancient TCM Pills for Constipation Treatment Based on Data Mining

作　　者：蓝海[1] 潘雨薇[1] 黄斯[1] 佟义 赵国平[1] LAN Hai;PAN Yu-wei;HUANG Si;TONG Yi;ZHAO Guo-ping(Medical College of Jinan University,Guangzhou 510632, China)

机构地区：[1]暨南大学医学院,广东广州510632

出　　处：《中国中医药信息杂志》2016年第12期41-43,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的运用数据挖掘技术分析古代通便丸剂的用药配伍规律,为临床用药及药物研发提供参考。方法检索《中华医典》(第五版)中收录的古籍,整理具有明确通便作用的丸剂相关文献,对所涉及药物的使用频次、所属类别进行统计,采用Apriori算法模型进行关联分析。结果经筛选,共纳入古代通便丸剂178首,涉及药物173味。使用频次最高的药物为蜂蜜,达121次(67.98%),其次是大黄、火麻仁、枳壳等;使用频次最高的药物类别为泻下药,其次为理气药、补虚药等;常用药对有大黄-羌活、大黄-肉桂、大黄-郁李仁等。结论《中华医典》收录古籍中通便丸剂用药配伍具有一定规律,可为现代临床用药及药物研发提供参考。Objective To analyze the medication and compatibility laws of ancient TCM pills for constipation treatment based on data mining; To provide references for clinical medication and medical research. Methods The ancient pills for the constipation treatment were enrolled and processed with information standardization by retrieving the fifth edition of the Zhong Hua Yi Dian. The useage frequency and categories of medicine were put into statistics.Apriori algorthm was used to conduct association analysis. Results After screening, totally 178 ancient TCM pills for constipation treatment were included, which related to 173 herbs. Honey, with the highest useagefrequency, appeared 121 times (67.98%), followed by Rhei Radix et Rhizoma, Cannabis Semen, and Aurantii Fructus. The medicine with the highest useage frequency was purgating medicine, followed by regulating-qi medicine and tonifying-deficieny medicine; the commonly used medical pairs were Rhei Radix et Rhizoma-Notopterygii Rhizoma et Radix, Rhei Radix et Rhizoma-Cinnamomi Cortex, and Rhei Radix et Rhizoma-Pruni Semen. Conclusion Medication and compatibility of ancient TCM pills for constipation treatment in the show certain laws, which can provide references for modern clinical medication and medical research.

关 键 词：中华医典 通便 丸剂 用药规律 数据挖掘 

分 类 号：R256.35[医药卫生—中医内科学] R2-05[医药卫生—中医学]