反复呼吸道感染患儿细胞免疫和血清免疫球蛋白、IgG亚类及水平分析  

Cellular immunity and serum levels of immunoglobulin and IgG subclasses in children with recurrent respiratory tract infection

作　　者：高晓敏[1] GAO Xiao-min(Department o f Pediatrics , Shaanxi People's Hospital yXV an 1 1006d>, Shaanxi, China)

机构地区：[1]陕西省人民医院儿科,陕西西安710068

出　　处：《川北医学院学报》2016年第3期370-372,共3页Journal of North Sichuan Medical College

摘　　要：目的:探讨患儿反复呼吸道感染(RRTI)与细胞免疫和血清免疫球蛋白、Ig G亚类及水平相关性。方法:选取反复呼吸道感染患儿30例作为观察组,另择取健康体检儿童30名作为对照组,观察两组患儿血清免疫球蛋白、细胞免疫和Ig G亚类水平以及Ig G亚类在缺陷免疫球蛋白中的分布。结果:1观察组患儿Ig M明显低于对照组,差异有统计学意义(P<0.05);2观察组患儿Ig G2、Ig G4明显低于对照组,差异有统计学意义(P<0.05);3观察组检测出缺陷Ig G亚型共14例,占46.7%,其中单项缺陷8例,占所有Ig G亚型的57.1%,其中Ig G4为最主要亚型,占35.7%,其次为Ig G3,占14.3%;联合缺陷共6例,占42.9%,主要为Ig G2+Ig G4,占35.7%;4观察组患儿CD3、CD4水平明显低于对照组,差异有统计学意义(P<0.05)。结论:反复呼吸道感染患儿多为具有荚膜多糖成分的细菌导致,患儿多伴Ig M、Ig G2+Ig G4以及CD3+、CD4+T细胞的紊乱。Objective: To investigate the correlation between and serum immunoglobulin, IgG subclasses and the level of serumimmunoglobulin in children with recurrent respiratory tract infection (RRTI). Methods:30 children with recurrent respiratory tract infectionwere selected as observation group,the other 30 healthy children were selected as control group. Serum levels of immunoglobulin,cellular immunity,IgG subclasses and IgG subclasses in the two groups were observed. Results: IgM was significantly lower in theobservation group than that in the control group (P <0. 05) ;IgG2 and IgG4 were significantly lower in the observation group than thoesin the control group ( P < 0. 0 5 ). In the observation group, there were 14 cases of IgG subtype, accounting for 46. 7% . Among them,8cases were single defects, which accounted for 57. 1 % of all IgG subtypes, IgG4 being the most important subtype, accounting for 35.7 % (5 /1 4 ) , followed by IgG3 , accounting for 14.3% (2 /1 4 ) ;joint defects in a total of 6 cases, accounting for 42. 9% , mainly forIgG2 + IgG4 ,accounting for 35. 7% (5 /1 4 ). The observation group with CD3 and CD4 levels were significantly lower than those of thecontrol group (P < 0. 0 5 ). Conclusion:Recurrent respiratory tract infection lead to the capsular polysaccharide of bacteria with c IgM ,IgG2 + IgG4 and CD3 + , CD4 + T cell disorder in children.

关 键 词：呼吸道感染 免疫球蛋白 细胞免疫 IGG 

分 类 号：R725.6[医药卫生—儿科]