超声弹性成像在兔深静脉血栓分期诊断的研究  

Application of ultrasound elastography in diagnosis for the stagesof deep vein thrombosis in a rabbit model

作　　者：吴戴红[1] 杜微云[1] 胡志文[1] 陈俏利[1] Wu Daihong;Du Weiyun;Hu Zhiwen;Chen Qiaoli(Department o f Medical Ultrasound, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, China)

机构地区：[1]广州医科大学附属广州市第一人民医院超声医学科,广州510180

出　　处：《新医学》2016年第7期433-436,共4页Journal of New Medicine

基　　金：广东省科学技术厅立项(20120314)

摘　　要：目的探讨超声弹性成像技术在兔深静脉血栓分期诊断的应用价值。方法选择20只新西兰大白兔,随机分为4组,A组为对照组、B组为急性组、C组为亚急性组、D组为慢性组。A组建立假手术组模型,其余3组均建立下腔静脉血栓模型,分别于7 d、21 d、3个月后用超声弹性成像技术对兔下腔静脉血栓进行检查,然后处死动物,剪取下腔静脉进行组织学检查。结果组织学检查显示,A组解剖后下腔静脉内未见血栓形成,B组为新鲜的混合血栓,C组混合型血栓脱水回缩、开始与血管壁分离,D组为陈旧性混合血栓。超声弹性成像技术检查结果显示,A组中下腔静脉内均显示以红色为主、B组以绿色为主、C、D组以蓝色为主。B组下腔静脉血栓显色色度与C、D组比较差异均有统计学意义(P均<0.017),C、D组间下腔静脉血栓显色度比较差异无统计学意义(P>0.017)。结论超声弹性成像技术可初步估测兔深静脉血栓分期。Objective To evaluate the application value of ultrasound elastography in diagnosis forthe stages of deep vein thrombosis in a rabbit model. Methods Twenty New Zealand white rabbits were randomlydivided into the groups A ( control group) , B ( acute group) , C ( subacute group) and D ( chronicgroup). Sham surgery model was established in the group A and inferior vena cava thrombosis model was establishedin the other three groups. The inferior vena cava thrombosis was evaluated by using ultrasound elastographyat 7 d, 21 d and 3 months after model establishment. Then, the animals were sacrificed for histological examinationof the inferior vena cava Results Histological examination revealed no thrombosis formation in theinferior vena cava in group A , new mixed thrombosis in group B, mixed thrombosis was dehydrated and retractedand began to separate from the vascular wall in group C and old mixed thrombosis in group D. Ultrasoundelastography displayed that a majority of inferior vena cava was seen as red in group A , green in group B andblue in groups C and D. The degree of color of inferior vena cava thrombosis in group B significantly differedfrom those in groups C and D (both P <0. 017). No statistical significance was documented between groups Cand D in terms of the degree of color of inferior vena cava thrombosis (P >0. 017 ). Conclusion Ultrasoundelastography can be utilized to preliminarily estimate the staging of deep vein thrombosis in a rabbit model.

关 键 词：超声弹性成像 兔下腔静脉血栓模型 分期 

分 类 号：R543.6[医药卫生—心血管疾病]