辅酶Q10对扩张型心肌病患者的疗效研究  

The efficcy of Coenzyme Q10 in Patients With Dilated Cardiomyopathy

作　　者：林斌[1] LIN - Bin(Department of Cardiology ,The People's Hospital of Meizhou,Guangdong,Meizhou 514031,China)

机构地区：[1]广东省梅州市人民医院心血管内一科,广东梅州514031

出　　处：《吉林医学》2016年第7期1627-1629,共3页Jilin Medical Journal

基　　金：广东省梅州市医药卫生立项(2014-B-30)

摘　　要：目的:观察辅酶Q10对扩张型心肌病(DCM)患者心功能、心室重构及预后的影响,探讨其治疗DCM的机制。方法:选取就诊的100例DCM患者,均接受基础治疗。并按随机数字表法分为观察组52例和对照组48例。观察组加辅酶Q10,随访3个月后观察治疗的有效率、左心室射血分数(LVEF)、左心室收缩末期容积(LVDS)、左心室舒张末期容积(LVDD)、血浆脑钠肽前体(NT-pro BNP)的变化。结果:与对照组比较,观察组的临床疗效显效率和总有效率均较高,LVEF上升,差异有统计学意义(P<0.01),而LVDD与LVDS缩小、NT-pro BNP水平明显下降,差异有统计学意义(P<0.05)。结论:在传统疗法治疗DCM患者基础上,口服常规剂量的辅酶Q10可提高临床疗效。Objective To found the Coenzyme Q10 treatment^ efficacy in patients with dilated cardiomyopathy(DCM). MethodA total of 100 patients of dilated cardiomyopathy were selected. According to random number table method, 100 cases were dividedinto experimental group 52 cases and control group each 48 cases ; patients in both groups treatment were on the basis of conventionaltreatment methods. Coenzyme Q10 were given in the experimental group. Left ventricular ejection vraction (LVEF) ,Leftventricular diastolic dimension (LVDD) ,Left ventricular end - systolic dimension (LVDS) ,Plasma amino - terminal pro - Brainnatriuretic peptide (NT - proBNP) level were observed before and after three months treatment. Results Compared with controlgroup,the dilated cardiomyopathy patients? LVEF was obviously improved, the different was statistically significant (P < 0. 01),LVDD,LVDS and NT - proBNP level also decreased at 3 months compared with that in observation group,the different was statisticallysignificant (P <0. 05). Conclusion In additional to the conventional therapy on DCM patients,oral regular doses of CoenzymeQ10 can improve therapeutic efficacy.

关 键 词：辅酶Q10 扩张型心肌病 疗效 

分 类 号：R542.2[医药卫生—心血管疾病]