心房颤动患者抗凝治疗前后微栓子及血浆D-二聚体水平观察  

Observation on microembolic signal and D-dimer level of atrial fibrillation patients before and after anticoagulant therapy

作　　者：徐云[1] 王兵[1] 蒋丽娇[1] 陆小平[1] 赵晓英[1] 王芳[1] Xu Yun;Wang Bing;Jiang Li-jiao;Lu Xiao-ping;Zhao Xiaoying;Wang Fang(Department of Cardiology, Suzhou Wuzhong Peopled Hospital, Suzhou Jiangsu 215128, China)

机构地区：[1]苏州市吴中人民医院心内科,江苏苏州215128

出　　处：《实用心电学杂志》2016年第3期210-212,共3页Journal of Practical Electrocardiology

摘　　要：目的观察心房颤动患者华法林治疗前后微栓子检出率及血浆D-二聚体水平。方法选择CHADS2评分為1分的持续性房颤患者40例，每例患者华法林抗凝治疗前后分别行微栓子监测和D-二聚体水平检查，比较治疗前后结果差异。结果抗凝治疗前微栓子阳性12例、阴性28例，治疗后微栓子阳性5例、阴性35例，抗凝治疗后微栓子检出率显著降低（30.0%12.5%,尤2=3.66,P<0.05);D-二聚体水平抗凝治疗前为（273±81)治疗后为（170±67)pg/L。治疗后血浆D-二聚体水平显著降低〇=10.09,P<0.05)。结论微栓子与D-二聚体水平均可以作为房颤患者栓塞风险的评估指标。Objective To observe the microembolic signal(MES) and D-dimer level of atrial fibrillation patients before and after warfarin anticoagulant therapy. Methods A total of 40 persistent atrial fibrillation patients with CHADS2 score ^1 were selected. Each of research object underwent MES monitoring and D-dimer level detection before and after warfarin anticoagulant therapy. We compared the results before and after the treatment. Results Before anticoagulant therapy, there were 12 cases with positive MES and 28 with negative MES; after the treatment, 5 cases were positive in MES and 35 were negative. The positive rate of MES significantly decreased after anticoagulant therapy(30. 0% 仍. 12. 5% , , =3. 66, P <0? 05). The level of D-dimer was (273 ±81) (xg/Lbefore anticoagulant therapy and (170 ±67) (xg/L after the therapy. The level of plasmatic D-dimer significantly reduced after the treatment ( ^ = 10. 09, P < 0. 05 ). Conclusion Both of MES and D-dimer level can be regarded as risk evaluation indicators of embolism in atrial fibrillation patients.[ Key words ] atrial fibrillation ; warfarin ; anticoagulant therapy; mcroembolic signal; D-dimer

关 键 词：心房颤动 华法林 抗凝治疗 微栓子 D-二聚体 

分 类 号：R541.75[医药卫生—心血管疾病]