Bromodomain-like折叠类型模板的设计  

Design of a Bromodomain-like Folding Type Template

作　　者：李晓琴[1] 张春城[1] LI Xiaoqin;ZHANG Chuncheng((College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《北京工业大学学报》2016年第10期1572-1580,共9页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(21173014);北京市自然科学基金资助项目(4112010)

摘　　要：针对折叠类型分类中所选天然模板普适性不足的问题,提出了Bromodomain-like折叠类型模板的设计方法.选SCOPe Astral 2.03序列相似度小于40%并且分辨率高于0.25 nm的52个可用Bromodomain-like折叠样本,基于多结构比对结果及数据分析,建立了折叠类型家族模板的设计方法.利用系统聚类方法构建了家族模板的系统聚类图,提出了蛋白质折叠类型模板的设计方法,并用于该折叠类型的模板设计.结果表明:设计模板具有普适性,可用于蛋白质折叠类型分类.For the problem that the universal shortage of natural template for folding type classification,a design method of the Bromodomain-like folding type template was presented. 52 Bromodomain-like folding type samples whose sequence similarity is less than 40% were chosen and the resolution was higher than 0. 25 nm in the database of the SCOPe of astral 2. 03. Based on the results of multiple structure alignment and data analysis, the design method of the folding type family template was established. The clustering graph of family template was constructed using the system clustering method,and the design of the template of the folding type was completed. Results show that the design templates have universality,and the templates can be used for protein folding type classification.

关 键 词：折叠类型分类 模板设计 结构比对 系统聚类 

分 类 号：O641[理学—物理化学]