孕16～18周空腹血糖对妊娠期糖尿病的预测价值  

Measurement of fasting plasma glucose at 16-18 weeks of gestation in predicting gestational diabetes mellitus

作　　者：李萍[1] 林硕[1] 范建辉[1] 崔金晖[1] 陈新娟[1] Li Ping;Lin Shuo;Fan Jianhui;Cui Jinhui;Chen Xinjuan(Department o f Obstetrics and Gynecology,the Third Affiliated Hospital o f Sun Yat-sen University, Guangzhou 510630, China)

机构地区：[1]中山大学附属第三医院产科,广州510630

出　　处：《新医学》2016年第10期691-694,共4页Journal of New Medicine

摘　　要：目的探讨孕16~18周空腹血糖对妊娠期糖尿病（GDM)的预测价值。方法选择327例单胎孕妇，于妊娠16~18周测定空腹血糖、24~28周行口服糖耐量试验（OGTT)，应用受试者工作特征（ROC)曲线分析空腹血糖预测GDM的敏感度和特异度。结果妊娠16~18周孕妇的空腹血糖与OGTT各时相血糖均相关（P均<0.01)。空腹血糖预测GDM的ROC曲线下面积为0.67(95%C/0.61~0.72,P<0.001),诊断阈值为4.6mm〇l/L;多因素回归分析显示空腹血糖是GDM发生的影响因素（〇尺=3.567,95%C/1.709~7.446,P<0.01)。结论孕16~18周空腹血糖对GDM有预测价值。Objective To evaluate the value of fasting plasma glucose at 16-18 weeks of gestation in predicting gestational diabetes mellitus (G DM ). Methods A total of 327 singleton pregnant women received fasting plasma glucose test at 16-18 weeks of gestation and oral glucose tolerance test ( OGTT) at 24-28 weeks of gestation. The sensitivity and specificity of fasting plasma glucose as a predictor of GDM were evaluated byreceiver operating characteristic ( ROC) curve. Results The fasting plasma glucose at 16-18 weeks of gestationwas correlated with OGTT at 24-28 weeks of gestation at each time point (all P <0. 0 1 ). The area underroc curve ( AUC) for fasting plasma glucose in predicting GDM was 0. 67 (95% C/ 0. 61- 0. 72, P < 0. 001 )and the diagnostic threshold was 4. 6 mmol/L. Multivariate logistic regression analysis revealed that fastingplasma glucose was an independent risk factor of the incidence of GDM ( OR = 3. 567 , 95% Cl 1. 709-7. 446, P<0. 0 1 ). Conclusion Detection of fasting plasma glucose at 16-18 weeks of gestation can be utilized to predict the incidence of GDM.

关 键 词：妊娠期糖尿病 空腹血糖 预测 

分 类 号：R714.256[医药卫生—妇产科学]