miR-26a调控Sox6和Bhlhe22表达对胰岛素分泌的影响  

Effects of Sox6 and Bhlhe22 expression controlled by mi R-26a on insulin secretion

作　　者：柳岚[1] 桑丹[1] 曾玲[1] 蒋凤秀[1] 陆泽元[1] Liu Lan;Sang Dan;Zeng Ling;Jiang Fengxiu;Lu Zeyuan(Department of Endocrinology,the Eighth Hospital Affiliated to Zhongshan University(The People's Hospital of Futian District in Shenzhen City) 518033)

机构地区：[1]中山大学附属第八医院(深圳市福田区人民医院)内分泌科,518033

出　　处：《中国社区医师》2016年第34期7-8,共2页Chinese Community Doctors

基　　金：2013年深圳市科技计划项目(医疗卫生类);项目编号:201302179~~

摘　　要：目的:胰腺发育过程涉及多种转录因子和信号通路,在糖尿病的发病中起重要作用。mi RNA可以调控胰岛β细胞发育相关蛋白的表达。mi R-26a直接调节Sox6和Bhlhe22的表达以调控胰岛β细胞的发育,从而影响胰岛素分泌,参与糖尿病发病。Pancreatic development involved multiple transcription factors and signaling pathways,which played an important rolein the pathogenesis of diabetes mellitus.MiRNA can regulate the expression of related protein for the development of pancreaticbeta cells.MiR-26a regulated the expression of Sox6 and Bhlhe22 directly in order to regulate the development of pancreatic betacells,so as to affect the insulin secretion and participate in the pathogenesis of diabetes.

关 键 词：胰岛素 MIRNA 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]