胚胎停育患者血清及组织中IL-6表达  

Expression of IL-6 in serum and tissues of patients with diapause-destined embryo

作　　者：姚旋[1,2] 虞伟[1] 章琼[3] YAO Xuan;YU wei;ZHANG Qiong(Department of laboratory,Jinling Hospital Affiliated to Medical College of Nanjing University,Nanjing 210002 China;Department of laboratory,Jiangsu Zhongshan Ganbu LiaoyangYuan,Zhongshan 210014 China;Department of gynaecology and obstetrics,Jinling Hospital Affiliated to Medical College of Nanjing University, Nanjing 210002 China)

机构地区：[1]南京大学医学院附属金陵医院,南京军区南京总医院临床中心实验科,南京210002 [2]江苏省钟山干部疗养院检验科,南京210014 [3]南京大学医学院附属金陵医院,南京军区南京总医院妇产科,南京210002

出　　处：《现代仪器与医疗》2016年第6期35-37,共3页Modern Instruments & Medical Treatment

摘　　要：目的：检测胚胎停育患者血清及组织中白细胞介素-6（IL-6）表达水平，探讨IL-6对胚胎停育的影响。方法：将我院2014年5月~2016年5月收治的74例胚胎停育患者纳入胚胎停育组，并选取同期50名正常早孕女性、50名健康未孕女性，分别纳入早孕组、健康组，检测各组受试者血清IL-6水平及绒毛、蜕膜组织IL-6表达水平。结果：胚胎停育组与早孕组年龄、停经时间、孕次、孕囊直径比较，差异无统计学意义（P＞0.05）。胚胎停育组血清IL-6水平低于早孕组、健康组，早孕组血清IL-6水平高于健康组，差异有统计学意义（P＜0.05）；胚胎停育组绒毛组织、蜕膜组织IL-6表达水平均低于早孕组，差异有统计学意义（P＜0.05）。结论：胚胎停育患者血清及组织中IL-6表达水平显著下降，这可能是造成其早期胚胎停止发育原因之一。Objective:This study was conducted to detect the expression of interleukin-6(IL-6)in serum and tissuesof patients with embryonic loss and to discuss the effect of IL-6on the stop of embryo development.Methods:74casesof embryonic loss admitted to our hospital from May2014to May2016were included in the diapause-destined embryogroup,and50normal pregnant women and50healthy non-pregnant women were selected into the early pregnancy groupand the healthy group,respectively,the subjects of all three groups were detected the IL-6expression levels in serum,villi and decidua tissues.Results:There was no statistically significant difference in age,duration of menopause,timesof pregnancy,gestational sac diameter between embryo group and early pregnancy group.Serum IL-6Level in diapausedestinedembryo group was lower than in early pregnancy group and healthy group,and that in pregnancy group washigher than in healthy group,the difference was statistically significant(P<0.05);IL-6levels of villi and decidua tissuesin diapause-destined embryo group were both lower than in normal pregnancy group,the difference was statisticallysignificant(P<0.05).Conclusions:The level of IL-6in serum and tissues of the embryo is significantly decreased,whichmay be one of the reasons for the early diapause of embryo development.

关 键 词：胚胎停育 血清 绒毛组织 蜕膜组织 白细胞介素-6 

分 类 号：R446[医药卫生—诊断学]