标准大骨瓣开颅术对重型创伤性颅脑损伤患者血清NSE及炎性因子水平的影响  

The influence of serum NSE and inflammatory factor level of patients with severe traumatic brain injury by standard large trauma craniotomy

作　　者：李学[1] 王增光[2] LI Xue;WANG Zeng-guang(Binhai Hospital of Tianjin Medical University General Hospital, Tianjin 300480, China;Tianjin Medical University General Hospital, Tianjin 300052, China)

机构地区：[1]天津医科大学总医院滨海医院,天津300480 [2]天津医科大学总医院,天津300052

出　　处：《中国处方药》2017年第1期1-2,共2页Journal of China Prescription Drug

基　　金：天津市应用基础与前沿技术研究计划重点项目(15JCZDJC36500)

摘　　要：目的研究标准大骨瓣开颅术对重型创伤性颅脑损伤(STBI)患者血清神经元特异性烯醇化酶(NSE)与炎性因子水平的影响。方法将2013年1月~2015年12月收治的100例STBI患者随机分为对照组50例,行传统大骨瓣开颅术治疗;治疗组50例,行标准大骨瓣开颅术治疗。比较两组患者手术前后血清NSE、炎性因子水平变化。结果术后治疗组NSE、IL-2、TNF-α低于术前,IL-4高于术前,且与对照组相比,治疗组NSE、IL-2、TNF-α水平低于对照组,IL-4高于对照组,差异均具统计学意义(P<0.05)。结论采用标准大骨瓣开颅术治疗重型创伤性颅脑损伤的效果显著,能减轻炎症反应,减少神经功能损伤。Objective To study the influence of serum NSE and inflammatory factor level of patients with severe traumatic brain injury(STBI)bystandard large trauma craniotomy.Methods100cases of patients with STBI in our hospital from the January2013to the December2015were randomly dividedinto the control group with50cases implemented the traditional big bone flap craniotomy for treatment and the treatment group with50cases implementedstandard large trauma craniotomy for treatment.To compared the serum NSE and changes of inflammatory factor level of patients before and after operation.Results After operation,the NSE,IL-2,TNF-αlevel of the treatment group were lower than those before the treatment,the IL-4was higher than before;comparison of the indexes of the control group after operation,the NSE,IL-2,TNF-αlevel of the treatment group were lower,and the IL-4was higher,and there were statistical significance(P<0.05).Conclusion It is able to alleviate the inflammatory response and reduce the nerve function deficit to get asignificant effect of patients with severe traumatic brain injury by standard large trauma craniotomy.

关 键 词：标准大骨瓣开颅术 重型创伤性颅脑损伤 血清NSE 炎性因子 

分 类 号：R651.15[医药卫生—外科学]