银杏叶口服多剂型指纹图谱及黄酮成分质量评价研究  

Study on Fingerprint and Quality Evaluation of Flavonoids in Ginkgo Biloba Leaves of Various Oral Dosage Forms

作　　者：钟媛媛[1,2] 王京辉[2] 陈晶[2] 郭洪祝[1,2] 陈有根[2] 傅欣彤[2] Zhong Yuan-yuan;Wang Jing-hui;Chen Jing(Department of TCM Chemistry,TCM School,Beijing TCM University,Beijing 100102,China;Beijing Key Lab. Analysis and Evaluation on Chinese Medicine,Beijing Institute of Drug Control,Beijing 102206, China)

机构地区：[1]北京中医药大学中药学院中药化学系,北京100102 [2]北京市药品检验所中药成分分析与生物评价北京市重大实验室,北京102206

出　　处：《中国医药导刊》2016年第12期1284-1286,共3页Chinese Journal of Medicinal Guide

基　　金：国家科技重大专项课题-中药质量标准研究和信息化体系建设平台(编号:2012ZX09304005);课题名称:口服银杏叶制剂指纹图谱研究

摘　　要：目的:建立银杏叶多种口服制剂的指纹图谱,利用黄酮苷峰面积比评价及控制其质量。方法:用HPLC色谱法,色谱柱Inertsil ODS-3 C18,检测波长360nm,以中药色谱指纹图谱相似度评价系统分析,对比分析特征性黄酮类成分。结果:通过相似度及特征色谱峰比例制定了区分样品质量的限度。结论:本研究方法简便、重复性良好,适用于不同剂型银杏叶口服制剂指纹图谱的建立及不同制剂质量评价。Objective: To establish the fingerprint of various oral preparations of Ginkgo biloba leaves,and to evaluate and control the quality of the area ratio of flavonoid glycosides. Methods:The characteristics of the flavonoids were compared and analyzed by HPLC with Inertsil ODS-3 C18 column and the traditional Chinese medicine chromatographic fingerprint similarity evaluation system. The detection wavelength was 360 nm. Results: The limit of the quality of the sample was established by the similarity and the proportion of the characteristic peaks.Conclusion: The method is simple and reproducible,and can be used to establish the fingerprints of Ginkgo biloba leaves in different dosage forms and the quality evaluation of different preparations.

关 键 词：银杏叶 剂型 指纹图谱 高效液相色谱法 黄酮苷 峰面积比 

分 类 号：R286.0[医药卫生—中药学]