树豆内酯A粗品皂化产物的化学结构鉴定  

Structural Identification on the Saponification Products of Raw Cajanolactone A

作　　者：胡阳亮 沈小玲[1] 陈梅果[1] 胡英杰[1] HU Yang-liang;SHEN Xiao-ling;CHEN Mei-guo;HU Ying-jie(Laboratory of Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China)

机构地区：[1]广州中医药大学热带医学研究所中药新药发现实验室,广州510405

出　　处：《热带亚热带植物学报》2017年第1期93-97,共5页Journal of Tropical and Subtropical Botany

基　　金：广东省高等学校创新强校工程创新中药研发团队项目(E1-KFD015141K05)资助~~

摘　　要：对天然产物树豆内酯A进行皂化反应以期获得具有降血糖、降血脂活性的天然药物先导物树豆酮酸A。利用含有树豆内酯A和球松素各约50%的粗品,经0.65%KOH含水乙醇回流3.5 h皂化,产物经柱层析分离纯化获得皂化产物;通过理化和波谱学分析鉴定产物的化学结构。分离并鉴定了全部5个皂化产物,除了预期产物树豆酮酸A以外,其余4个低得率的副产物结构分别为1-(2,6-二羟基-4-甲氧基苯基)乙酮(2)、球松素查尔酮(3)、cajanotone(4)和1个新化合物(1),化合物1鉴定为CAA的异构体,命名为树豆酮酸B(Cajanonic acid B)。这为进一步研究开发树豆(Cajanus cajan)叶生物活性成分提供了新的实验依据。The aim of this work was to obtain a natural hypoglycemic and hypolipidemic drug lead cajanonic acid A (CAA) by saponification of a natural product cajanolactone A (CLA). A mixture containing about both 50%amount of CAA and pinostrobin was treated with 0.65% KOH in aqueous ethanol for 3.5 h under reflux, the mixed products were isolated through column chromatography and identified by physico-chemical and spectroscopic analysis. Besides the expected product CAA, four minor saponificative products were obtained, and identified as 1-(2,6-dihydroxy-4-methoxyphenyl)-ethanone (2), pinostrobin chalcone (3), cajanotone (4), andcompound 1. Compound 1, a structural isomer of CAA, was found to be a new compound and named as cajanonicacid B. These would provide a new experimental basis for the further research and development bioactive component of Cajanus cajan leaves.

关 键 词：树豆内酯A 皂化 树豆酮酸A 树豆酮酸B 

分 类 号：R284[医药卫生—中药学]