超重及肥胖青年大学生血清内脂素水平与中心动脉收缩压的关系  

Relationship between level of serum visfatin and central aortic systolic blood pressure in overweight or obese young college students

作　　者：廖明媛 田建伟[1] 王新宴[2] 许波[2] 于心亚[1] 张娜[3] 张亚华[4] LIAO Ming-yuan;TIAN Jian-wei;WANG Xin-yan;XU Bo;YU Xin-ya;ZHANG Na;ZHANG Ya-hua(Department o f Cardiovasology, Chinese PLA Air Force General Hospital, Beijing 100142, China)

机构地区：[1]中国人民解放军空军总医院心血管内科,北京100142 [2]中国人民解放军空军总医院特诊科,北京100142 [3]河北北方学院,张家口075000 [4]第四军医大学学员旅,西安710000

出　　处：《中国循证心血管医学杂志》2016年第11期1323-1325,1340,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：科技基础性工作专项(2013FY114000)

摘　　要：目的检测中国超重及肥胖青年大学生血清内脂素的水平，探讨血清内脂素水平与中心动脉收缩压的关系。方法从西安工业大学中央校区148例17~23岁的超重及肥胖青年大学生中筛选出高血压患者45例为高血压组，血压正常者103例为对照组。使用SphygmoCor■无创主动脉脉搏分析仪测量中心动脉收缩压；测量外周血压；检测血清内脂素水平，并分析其与中心动脉收缩压、外周肱动脉收缩压、舒张压及平均动脉压的关系。结果高血压组的中心动脉收缩压、外周肱动脉收缩压、外周肱动脉舒张压、外周肱动脉平均动脉压均高于对照组，差异具有统计学意义（P均<0.001)。高血压组血清内脂素水平较对照组高[(227.33±30.93)^g/Lvs.(201.58±34.03)^g/L]，差异具有统计学意义（P<0.001)。血清内脂素水平与中心动脉收缩压、外周肱动脉收缩压、外周肱动脉舒张压、外周肱动脉平均压呈正相关，相关系数分别为0.498、0.489、0.414、0.460(P均<0.001)。结论超重及肥胖青年大学生中高血压患者血清内脂素水平高于血压正常者，并且内脂素与中心动脉收缩压及外周血压呈正相关，预示内脂素可能参与青年大学生肥胖相关性高血压的发生及发展。Objective To detect the level of serum visfatin in overweight or obese young college studentsin China,and investigate the relationship between it and central aortic systolic blood pressure(CSBP).MethodsThe overweight or obese young college students(n=148and aged from17to23)were chosen from the centralcam pus of X i’an Technological University,and among them45students with hypertension were included inhypertension group and103with normal blood pressure(BP)were included in control group.CSBP was detectedby using non-invasive SphygmoCor aortic pulse analyzer,and peripheral blood pressure was m easured by usingmercury sphygmomanometer.The level of serum visfatin was detected by using enzym e-linked immunosorbentassay(ELISA),and the relationship among visfatin,CSBP,peripheral brachial artery systolic pressure(BASP),peripheral brachial artery diastolic pressure(BADP)and brachial artery mean arterial pressure(BAMAP)wasanalyzed.Results CSBP,BASP,BADP and BAMAP were all higher in hypertension group than those in controlgroup(all P<0.001).The level of serum visfatin was higher in hypertension group than that in control group[(227.33±30.93)p g/L vs.(201.58±34.03)pg/L,P<0.001].The level of serum visfatin was positively correlated to CSBP,BASP,BADP and BAMAP(r=0.498,0.489,0.414,0.460,all P<0.001).Conclusion The hypertensive patientsin overweight or obese young college students have higher level of serum visfatin compared with those with normalBP.The level of serum visfatin is positively correlated to CSBP and peripheral BP,which indicates that visfatin mayparticipate the occurrence and development of obesity-related hypertension in young students.

关 键 词：内脂素 中心动脉收缩压 青年 超重及肥胖 

分 类 号：R5[医药卫生—内科学]