不同剂量布地奈德雾化吸入治疗AECOPD临床疗效观察  

Different Doses of Budesonide Inhalation Therapy AECOPD Clinical Observation

作　　者：吴国斌[1] 袁平[1] 曾省都[1] 赖庆文[1] 刘惟优[1] WU Guo-bin;YUAN Ping;ZENG Sheng-du;LAI Qing-wen;LIU Wei-you(First Affiliated Hospital of Gannan Medical Respiratory Medicine, Ganzhou Jiangxi 341000, China)

机构地区：[1]赣南医学院第一附属医院呼吸内科,江西赣州341000

出　　处：《药品评价》2016年第24期23-24,共2页Drug Evaluation

摘　　要：目的:探讨不同剂量布地奈德混悬液雾化吸入治疗AECOPD临床疗效观察。方法:抽取2014年1月—2015年12月间,于我院呼吸内科住院的120例AECOPD患者作为研究对象,将患者随机分为四组,高剂量组予4mg布地奈德雾化吸入(高剂量组予4mg布地奈德混悬液雾化吸入bid);中剂量组3mg布地奈德雾化吸人(中剂量组予3 mg布地奈德混悬液雾化吸入bid);低剂量组予2mg布地奈德雾化吸人(低剂量组予2 mg布地奈德混悬液雾化吸入bid);甲强龙组患者给予泼尼松龙针剂40 mg静脉推注,bid,对比四组患者的治疗效果。结果:四组患者治疗后咳嗽、喘息和哮鸣音临床症状评分对比无差异,P>0.05。患者治疗后,高剂量组患者肺功能与低剂量组相比有明显较优,P<0.05。高剂量组、中剂量组、低剂量组患者治疗后肺功能状况,动脉气血情况与甲强龙对比无差异,P>0.05。结论:吸入布地奈德混悬液治疗效果与静脉给予甲强龙相似,但吸入布地奈德不良反应少,适当增加布地奈德剂量能改善患者肺功能,可在临床推广运用。Objective: To investigate different doses of budesonide inhalation therapy AECOPD clinical efficacy outlook. Methods: Between January 2014 to December 2015, our hospital 120 cases of respiratory medicine hospitalized AECOPD patients for the study, patients were randomly divided into four groups, the high dose group was given 4 mg budesonide inhalation (high dose to 4 mg budesonide inhalation bid), the dose of 3mg budesonide aerosol inhalation (3 mg dose group was treated with budesonide inhalation bid), low-dose group to 2 mg budesonide aerosol inhalation (low-dose group were given 2 mg budesonide inhalation bid); methylprednisolone group were treated with prednisolone 40 mg intravenous bolus injection, bid, contrast four group patient outcomes. Results: Four patients after treatment, coughing, wheezing and wheezing comparative clinical symptom score no difference,P>0.05. After the patients, lung function in patients with high-dose group and low dose group produced significantly better compared, P<0.05. Highdose group, middle dose group, patients after treatment side effects of low-dose group compared with the incidence of methylprednisolone group were significantly lower, P<0.05. Conclusion: Inhaled budesonide suspension treatment with intravenous methylprednisolone similar, but less side effects inhaled budesonide, an appropriate increase in the dose of budesonide improves lung function in patients, in clinical use.

关 键 词：布地奈德 雾化吸入 AECOPD 

分 类 号：R563.9[医药卫生—呼吸系统]