5-氨基酮戊酸-光动力治疗面部日光性角化病的疗效和抗光老化评价  

The Clinical Effect and Light Aging Resistant of 5-aminolevulinic Acid Photodynamic Therapy in the Treatment of Actinic Keratosis

作　　者：布文博[1] 张孟丽[1] 张倩[1] 陈旭[1] 方方[1] BU Wen-bo;ZHANG Meng-li;ZHANG Qian;CHEN Xu;FANG Fang(Institute of Dermatology,Chinese Academy of Medical Sciences & Peking Union Medical College,Nanjing 10042,Jiangsu,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院,江苏南京210042

出　　处：《中国美容医学》2017年第1期7-10,共4页Chinese Journal of Aesthetic Medicine

基　　金："协和青年基金";"中央高校基本科研业务费专项资金"(3332015116)

摘　　要：目的:探讨5-氨基酮戊酸-光动力疗法(ALA-PDT)在面部日光性角化病(AK)治疗中的临床疗效,同时观察其抗光老化作用和调查患者满意度。方法:择选我院2015年1月至2015年11月在门诊治疗的20例日光性角化病患者作为研究对象,行ALA-PDT治疗,将ALA配置成20%溶液涂于皮损,4~6h后行635nm红光照射,能量密度为80~100 J/cm^2,时间约20 min,每周照射1次,共3~5次。结果:随访半年,疗效评价:18例患者完全缓解(90.0%),2例患者部分缓解(10.0%),未出现无效及再复发患者;抗光老化评价:患者治疗前平均色素评分4.1±1.25,治疗后平均色素评分2.8±1.15,平均降低1.3±0.66,变化有统计学意义(P<0.01);患者治疗前平均皱纹评分为5.8±0.95,治疗后平均皱纹评分为4.9±1.02,平均降低0.9±0.55,变化有统计学意义(P<0.01);患者满意度评分:95%的患者对治疗表示满意(7/20)和非常满意(12/20),平均满意度分值为3.55分。结论:对日光性角化病患者予以ALA-PDT治疗,疗效确切,抗光老化作用显著,患者满意度高,值得在临床中大力推广。Objective To observe the clinical effect and light aging resistant of 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis. Methods 20 cases of actinic keratosis patients in our hospital from 2015 january to 2015 november were as the research object,Aminolevulinic acid 20% solution was prepared,and applied to skin lesions, After 4-6 hours.The lesions were irradiated with red light at an energy density of 80 to 100 J/cm2 for 20 minutes.Totally,3 to 5 sessions of photodynamic therapy were given at a frequency of once a week. Results Follow-up 6 months,there were 18 patients with complete response(90.0%),two patients partial response(10.0%), no failure and recurrence case;the average pigment score was 4.1±1.25 before treatment and 2.8±1.15 after treatment,with an average decrease of 1.3±0.66, the change was statistically significant (P <0.01); the average wrinkle score was 5.8±0.95 before treatment and 4.9 ± 1.02 after treatment, with an average decrease of 0.9±0.55,the change was statistically significant (P <0.01). 95% of patients were satisfied (7/20) and very satisfied (12/20) with the treatment, the average satisfaction score is 3.55 points. Conclusion To be 5-aminolevulinic acid photodynamic therapy for actinic keratosis patients for treatment,efficacy,adverse reactions are mild,light aging resistance effect,patient satisfaction is high,is worth promoting in clinic.

关 键 词：5-氨基酮戊酸 光动力疗法 日光性角化病 临床疗效 抗光老化 患者满意度 

分 类 号：R339.38[医药卫生—人体生理学]