大黄消痔栓治疗湿热瘀阻型慢性非细菌性前列腺炎/慢性骨盆疼痛综合征临床研究  

Clinical Study on Dahuang Xiaozhi Suppository in Treating Chronic Abacterial Prostatitis/Chronic Pelvic Pain Syndrome of Moist Heat and Blood Stasis Syndrome

作　　者：王新平[1,2] 易剑锋[2,3] 田跃军[1] 邢喜平[2] 孟瑞霞[1] 张骕[1] 付生军[1] 杨立[1] WANG Xin-ping;YI Jian-feng;TIAN Yue-jun;XING Xi-ping;MENG Rui-xia;ZHANG Su;FU Sheng-jun;YANG Li(Institute of Urology of Lanzhou University, Gansu Nephron-Urological Clinical Center, Key Laboratory of Diseases of Urological System in Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China;Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China;Clinical School, Gansu University of Chinese Medicine, Lanzhou 730000, China)

机构地区：[1]兰州大学泌尿外科研究所甘肃省泌尿系统疾病临床医学中心甘肃省泌尿系统疾病研究重点实验室兰州大学第二医院,甘肃兰州730030 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]甘肃中医药大学临床医学院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2017年第3期22-25,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81060304);甘肃省中医药管理局科研课题(GEK-2015-63)

摘　　要：目的观察大黄消痔栓治疗湿热瘀阻型慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CABP/CPPS)的临床疗效。方法选取CABP/CPPS湿热瘀阻型患者200例,随机分为观察组和对照组各100例。2组均停用抗感染药物和其他制剂,予饮食及生活干预。对照组予前列安栓,观察组予大黄消痔栓,每次1粒,每日1次,纳肛,置入肛门3~4 cm。10 d为1个疗程,疗程间隔2 d,治疗3个疗程。观察2组临床疗效及治疗前后NIH慢性前列腺炎症状指数(NIH-CPSI)评分、前列腺液白细胞计数、卵磷脂小体、尿流率变化。结果观察组总有效率为100%(100/100),对照组为78%(78/100),观察组明显高于对照组(P<0.05)。与治疗前比较,2组前列腺液白细胞计数、NIH-CPSI评分均降低(P<0.01),观察组明显低于对照组(P<0.01);治疗后2组卵磷脂小体++++者均增多(P<0.01),观察组明显多于对照组(P<0.01);2组尿流率均升高(P<0.05),观察组高于对照组(P<0.01)。结论大黄消痔栓治疗湿热瘀阻型CABP/CPPS疗效显著,效果优于前列安栓。Objective To investigate the clinical efficacy of Dahuang Xiaozhi Suppository in treating chronicabacterial prostatitis/chronic pelvic pain syndrome(CABP/CPPS)of moist heat and blood stasis syndrome.Methods Two hundred patients of CABP/CPPS were randomly divided into control group and observation group,100cases in each group.2groups were disabled anti-infective meidicne and other preparations,and received diet and lifeintervention.The control group received the treatment of Qianliean Suppository,and the observation group receivedthe treatment of Dahuang Xiaozhi Suppository,one capsule each time,once a day,into the anus depth of about3–4cm.Ten days were a treatment course with two day interval between each course of treatment.The treatmentlasted for three courses.The clinical efficacy of the two groups was observed and compared.The indexes includingthe scores of NIH-CPSI,leukocyte count and lecithin corpuscles in prostatic fluid,and urinary flow rate wereevaluated.Results The total effective rate was100%(100/100)in the observation group and78%(78/100)in thecontrol group,and the observation group was much higher than control group(P<0.05).The scores of NIH-CPSI andleukocyte count in both groups were significantly lower after treatment(P<0.01),and those in observation group were significantly lower than those in control group(P<0.01).The cases with lecithin corpuscles++++in both groups weresignificantly more after treatment(P<0.01),and those in observation group were significantly more than those incontrol group(P<0.01).The peak flow rate and mean flow rate in both groups were higher after treatment(P<0.01),and it was higher in observation group(P<0.01).Conclusion The efficacy of Dahuang Xiaozhi Suppository intreating CABP/CPPS of moist heat and blood stasis syndrome is remarkable,and it is better than QianlieanSuppository.

关 键 词：大黄消痔栓 慢性非细菌性前列腺炎/慢性骨盆疼痛综合征 湿热瘀阻证 临床研究 

分 类 号：R277.573.3[医药卫生—中医学]