过敏原皮肤点刺试验结果与外周血嗜酸性粒细胞在儿童支气管哮喘临床应用中的意义  

Significance of allergen skin prick test and peripheral blood eosinophilic granulocyte in clinical application for pediatric bronchial asthma

作　　者：卢旭 冯海荣 赵禧 LU Xu;FENG Hai-rong;ZHAO Xi(Department of Pediatrics,Beijing Tongzhou District Maternal and Child Health Care Hospital, Beijing 101100, China)

机构地区：[1]北京市通州区妇幼保健院儿科,101100

出　　处：《中国现代药物应用》2017年第3期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的总结支气管哮喘(BA)儿童皮肤点刺试验(SPT)结果 ,探讨其与外周血嗜酸性粒细胞(EOS)在BA儿童中的临床诊断意义及两者之间的相关性分析。方法收集200例BA患儿的SPT及外周血EOS计数比例结果 ,探讨过敏原分布情况及与外周血EOS计数比例的相关性。结果 BA患儿200例中过敏原阳性者127例,占63.5%;吸入性过敏原阳性者120例,占60.0%,食物性过敏原阳性25例,占12.5%;食物性过敏原阳性以鸡蛋和牛奶过敏者多见,吸入性过敏原阳性以粉尘螨、屋尘螨、室外霉菌、艾蒿、猫毛、梧桐及柳树过敏者多见。BA儿童过敏原皮肤点刺试验阳性强度和外周血EOS计数比例间呈明显正相关(r=0.753,P<0.01)。结论粉尘螨及屋尘螨是BA儿童最常见的过敏原,SPT对BA在诊断方面有指导价值,外周血EOS为BA阶段性治疗提供有力的依据,但要避免其他因素对外周血EOS计数的影响。Objective To summarize outcomes by skin prick test (SPT) in children with bronchial asthma (BA), and to investigate significance of peripheral blood eosinophilic granulocyte (EOS) in clinical diagnosis of children with BA and their correlation. Methods A total of 200 ratio outcomes of SPT and peripheral blood EOS count in children with BA were collected for correlation investigation between allergen distribution and peripheral blood EOS count. Results Among 200 children with BA, there were 127 cases with positive allergen, accounting for 63.5%. There were 120 cases with positive inhaled allergens, accounting for 60.0% and 25 cases with positivefood allergens, accounting for 12.5%. Main allergens in cases with positive food allergens were egg and milk.Main allergens in cases with positive inhaled allergens included dermatophagoides farina, dermatophagoides pteronyssinus, outdoor mold, artemisia argyi, cat hair, Chinese parasol and willow. Positive intensity in allergenskin prick test for BA children had obviously positive correlation with peripheral blood EOS count (r=0.753, P<0.01).Conclusion Dermatophagoides farina and dermatophagoides pteronyssinus are common allergens for children withBA. SPT shows guiding value for diagnosis, and peripheral blood EOS provides valid reference in stage treatment of BA,while it is necessary to avoid effect by other influencing factors on peripheral blood EOS count.

关 键 词：儿童 支气管哮喘 过敏原 皮肤点刺试验 嗜酸性粒细胞 

分 类 号：R725.6[医药卫生—儿科]