胺碘酮治疗心律失常的效果分析及其对血清超敏C反应蛋白的影响  

Effect of Amiodarone in the Treatment of Arrhythmia and its Influence on Serum High Sensitive C Reactive Protein

作　　者：罗秋玲[1] LUO Qiu-ling(People's Hospital of Jianli County of Hubei Province, Jingzhou Hubei 433300, China)

机构地区：[1]湖北省监利县人民医院,湖北荆州433300

出　　处：《药品评价》2017年第1期51-54,共4页Drug Evaluation

摘　　要：目的:讨论和分析胺碘酮在治疗心律失常中的临床效果,研究其对心律失常患者的血清超敏C反应蛋白的具体影响。方法:选取了湖北省监利县人民医院于2016年3月至2016年9月期间收治的86例心律失常患者以随机的方法分成了治疗组(n=43)和对照组(n=43),治疗组患者服用胺碘酮片治疗,对照组患者服用心律平片治疗,比较两组心律失常患者的治疗效果,观察治疗前后两组患者血清超敏C反应蛋白的变化情况。结果:治疗组用药的总有效率为90.69%,明显高于对照组的总有效率69.76%,差异存在统计学意义(P<0.05);治疗组和对照组在治疗前的高切全血黏度、低切全血黏度、纤维蛋白原和血清超敏C反应蛋白没有明显的差异性,而治疗后两组间各项指标的差异存在统计学意义,治疗组的改善情况明显的优于对照组(P<0.05);两组治疗中出现不良反应发生率比较没有统计学意义(P>0.05)。结论:心律失常患者采用胺碘酮治疗的效果非常明显,患者的各项临床指标均有明显的改善,血清超敏C反应蛋白水平显著优于治疗前。Objective: To discuss the clinical effect of amiodarone in the treatment of arrhythmia, and the effects on serum high sensitive C reactive protein in patients with arrhythmia were analyzed. Methods: 86 patients with arrhythmia accepted treatments in People's Hospital of Jianli County of Hubei Province from March, 2016 to September, 2016 were randomly divided into treatment group (n=43) and control group (n=43). The treatment group of patients were taken the amiodarone treatment, while the control group of patients were taken the propafenone tablets treatment. Then, the changes of serum high sensitive C reactive protein of two groups of patients before and after treatment were observed. Results: The total effective rate in the treatment group was 90.69%, which was significantly higher than that in the control group of 69.76% (P<0.05). There was no obvious difference in the high blood viscosity, low shears whole blood viscosity, fibrinogen and serum high-sensitivity C reactive protein before treatment between the treatment group and the control group, and there were significant differences in the indexes between the two groups after treatment. The improvement of the treatment group was significantly better than that of the control group (P<0.05). The incidence of adverse reactions of two groups was not statistically significant (P>0.05). Conclusion: The effects of amiodarone in the treatment of arrhythmia are significant, with significantly improved clinical indicators. And the level of serum high sensitive C reactive protein are significantly better than that before treatment.

关 键 词：胺碘酮 心律失常 血清超敏C反应蛋白 治疗效果 

分 类 号：R541.7[医药卫生—心血管疾病]