复荣通脉胶囊对糖尿病大鼠脂代谢及内皮细胞iNOS表达的影响  

Effects of the Furong Tongmai capsule on lipid metabolism and expression of iNOS in endothelial cells of diabetic rats

作　　者：张淑芳[1] 吕树泉[1] 王猛[1] 苏秀海[1] 韩中千[1] 王晓蕴[1] 

机构地区：[1]河北省沧州中西医结合医院,河北沧州061001

出　　处：《中医临床研究》2017年第2期13-15,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:分析复荣通脉胶囊对糖尿病大鼠的血脂代谢、血管内皮细胞i NOS的影响。方法:选取30只Wistar大鼠为研究对象,采用随机数字表法,分为空白对照组10只,糖尿病大血管病变模型20只,然后将糖尿病大血管病变模型大鼠随机分为两组:模型对照组、复荣通脉治疗组(1.4g·kg^(-1)·d^(-1))。比较三组大鼠治疗后的血糖、血脂、i NOS表达情况。结果:1模型对照组治疗前后血糖水平均较空白对照组明显升高(P<0.01),模型对照组治疗前后血糖水平无明显差异(P>0.05);2治疗后,模型对照组的血清TC、TG水平较空白对照组明显升高(P<0.01);较模型对照组,复荣通脉治疗组TC、TG降低(P<0.01);3治疗后,较空白对照组,模型对照组主动脉i NOS表达明显升高(P<0.01),复荣通脉治疗组iNOS表达较模型对照组明显减少(P<0.01)。结论:复荣通脉胶囊可纠正脂代谢紊乱,下调i NOS表达,减轻主动脉内皮细胞损伤,达到减少大血管病变发生、发展的目的。Objective: To analyze the effect of the Furong Tongmai capsule on lipid metabolism and expression of iNOS in endothelial cells of diabetic rats. Methods: 30 Wistar rats were selected as the research objects, using random number table method, divided into the blank control group (10 rats), 20 rats model of diabetic macrovascular disease, then diabetic macrovascular disease model rats were randomly divided into 2 groups: the model control group, the Furong Tongmai treatment group. Blood glucose, lipids and iNOS expression after treatment in the 3 groups were compared. Results: In the model control group before and after treatment, blood glucose levels were increased significantly compared with the blank control group (P<0.01), in the model control group before and after treatment,blood sugar levels showed no significant difference (P>0.05). After the treatment, in the model control group, the serum TC and TG levels were significantly increased compared with the blank control group (P<0.01); compared with the model control group, TC, TC in the Furong Tongmai group were reduced (P<0.01). After treatment, compared with the blank control group, the aortic iNOS expression in the model control group was significantly increased (P<0.01); iNOS expression in the Furong Tongmai treatment group was decreased significantly than that in the model control group (P<0.01). Conclusion: The Furong Tongmai capsule can correct the disorder of lipid metabolism, decrease the expression of iNOS, reduce aortic endothelial cell injury and to reduce the occurrence of macrovascular disease and development.

关 键 词：糖尿病 大鼠 诱导型一氧化氮合酶 复荣通脉胶囊 

分 类 号：R587.1[医药卫生—内分泌]