不同他汀对冠脉介入患者胱抑素C影响的研究  

Different statins therapy for Cystatin C in percutaneous coronary intervention

作　　者：魏舒[1] 庄海峰[1] 魏传菊 娄明[2] 刘奕[2] WEI Shu;ZHUANG Hai-feng;WEI Chuan-ju(Department of Cardiac Catheterization Room, XuZhou Central Hospital,Xuzhou 221009 China;Department of Cardiology, XuZhou Central Hospital,Xuzhou 221009 China)

机构地区：[1]徐州市中心医院心导管室,江苏徐州221009 [2]徐州市中心医院心内科,江苏徐州221009

出　　处：《中国处方药》2017年第3期5-6,共2页Journal of China Prescription Drug

基　　金：徐州市科学技术局社会发展基金项目(XZZD1379)

摘　　要：目的探讨不同的他汀药物对于冠状动脉介入治疗患者术后血清胱抑素C的影响及其可能的机制。方法选择2014年1月~2015年9月在徐州市中心医院心内科住院行冠状动脉介入治疗患者150例,随机分为对照组、阿托伐他汀组和瑞舒伐他汀组。对照组术前3 d到术后3 d不给予任何他汀药物治疗;阿托伐他汀组术前3 d到术后3 d给予阿托伐他汀80 mg/d治疗,瑞舒伐他汀组术前3 d到术后3 d给予瑞舒伐他汀20 mg/d治疗,三组患者入院后常规测定血清胱抑素C,手术后48~72 h之间再次采血测定血清胱抑素C,比较三组之间术前、术后血清胱抑素C水平。结果三组患者术后血清胱抑素C水平均较术前升高,且差异有统计学意义(P<0.05),其中阿托伐他汀组和瑞舒伐他汀组患者术后血清胱抑素C升高程度均较对照组低,差异有统计学意义(P<0.05);但阿托伐他汀组和瑞舒伐他汀组患者术后血清胱抑素C升高程度相比,差异无统计学意义(P>0.05)。结论阿托伐他汀和瑞舒伐他汀短期、大剂量应用可以降低冠状动脉介入治疗术后血清胱抑素C的升高。Objective To investigate the impact of different statins on the concentration of cystatin C after Percutaneous Coronary Intervention and the probably mechanism.Methods One hundred and fifty patients who accept percutaneous coronary intervention are selected from Cardiology Department of Xuzhou Central Hospital from Jan.2014to Sep.2015.Those patients are randomly divided into three groups,the control group,the atorvastatin group and rosuvastatin group.The control group,is treated with no statin between3days before the surgery and3days after the surgery.The atorvastatin group,is treated with80mg/d atorvastatin between3days before the surgery and3days after the surgery.The rosuvastatin group is treated with20mg/d rosuvastatin between3days before the surgery and3days after the surgery.All three groups receive the test of cystatin C at the beginning and were tested again48～72hours afterthe surgery.The cystatin C level is tested after the surgery and compared with the level before the surgery.Results The cystatin C level of three groups after thesurgery is higher than the level before the surgery(P<0.05).The increase in the concentration of cystatin C of the atorvastatin group and the rosuvastatin group after the surgery is lower than control group and there is significant statistic difference(P<0.05).The increase in the concentration of cystatin C after the surgery has no significant difference between the atorvastatin group and rosuvastatin group(P>0.05).Conclusion Atorvastatin and rosuvastatin shortterm and high-dose therapy in Percutaneous Coronary Intervention can help lower the concentration of cystatin C after the surgery.

关 键 词：对比剂肾病 经皮冠状动脉介入治疗 他汀 胱抑素C 

分 类 号：R541.4[医药卫生—心血管疾病]