氟比洛芬酯与曲马多术后镇痛效果及药物不良反应的Meta分析  

A Meta-analysis of flurbiprofen axetil versus tramadol in postoperative analgesia effect and adverse drug reactions

作　　者：邹良旺 赵喜越[2] 邱恩毅 徐李娟[2] 单云峰[2] ZOU Liangwang;ZHAO Xiyue;QIU Enyi;XU Lijuan;SHAN Yunfeng(Department of Surgery,Wenzhou Longwan First People’s Hospital, Wenzhou, 325024;Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015;Department of Radiotherapy and Chemotherapy,Wenzhou Central Hospital, Wenzhou, 325000)

机构地区：[1]温州市龙湾区第一人民医院外科,浙江温州325024 [2]温州医科大学附属第一医院麻醉科,浙江温州325015 [3]温州市中心医院放化疗科,浙江温州325000

出　　处：《温州医科大学学报》2017年第3期206-210,共5页Journal of Wenzhou Medical University

摘　　要：目的:比较分析氟比洛芬酯与曲马多的术后镇痛效果及药物不良反应发生情况。方法:检索中国知网、万方数据库等中文数据库及Medline、Pubmed等外文数据库,收集2006年1月至2015年5月间有关氟比洛芬酯与曲马多术后镇痛效果比较的临床随机对照试验;根据Cochrane系统评价手册5.0对纳入研究的文献进行质量评价;应用RevMan5.1软件对相应研究指标进行Meta分析。结果:共纳入10篇文献,共计728例患者;疗效方面:氟比洛芬酯组术后镇痛效果与曲马多组比较差异无统计学意义(P>0.05);药物不良反应方面:氟比洛芬酯组恶心、呕吐的发生率显著低于曲马多组(RR=0.36,95%CI:0.26~0.50,P<0.001),头晕发生率也显著低于曲马多组(RR=0.46,95%CI:0.26~0.83,P=0.01);漏斗图表明各项指标没有显著性发表偏倚。结论:氟比洛芬酯术后镇痛的效果与曲马多相当,但恶心、呕吐、头晕等药物不良反应的发生率都明显低于曲马多。Objective: To compare and analyze flurbiprofen axetil with tramadol in postoperative analgesic effect and the occurrence of adverse drug reactions. Methods: All the randomized controlled trials referring to the comparison of flurbiprofen axetil and tramadol in postoperative analgesia effect and adverse drug reactions were searched in the domestic and foreign databases (such as CNKI, WanFang database, Medline and Pubmed) in January 2006 to May 2015. The enrolled published literatures were analyzed using Meta-analysis method with RevMan 5.1 statistical analysis software. Results: Ten separate clinical randomized controlled trials including 728 cases were researched with the Meta-analysis. Objective responsiveness: there is no significant difference between the postoperative analgesia effect of flurbiprofen axetil group and that of tramadol group; But in the adverse drug reactions: the incidence of nauses and vomiting were lower in the flurbiprofen axetil group than that in the tramadol group (P<0.001), the RR and 95%CI were 0.36 (0.26-0.50). The incidence of dizziness was lower in the flurbiprofen axetil group than that in the tramadol group (P=0.01), the RR and 95%CI were 0.46 (0.26-0.83). The funnel plots showed no significant publication bias in each indexes. Conclusion: The roles of postoperative analgesia effect in flurbiprofen axetil group are similar to tramadol group, but the incidence of adverse drug reactions are less in the flurbiprofen axetil group than that in the tramadol group.

关 键 词：氟比洛芬酯 曲马多 药物不良反应 META分析 

分 类 号：R614[医药卫生—麻醉学]