水合氯醛透皮贴剂的药物动力学及生物利用度研究  

Research of pharmacokinetics and bioavailability in chloral hydrate transdermal patch

作　　者：曾春香[1] 严俊珍[1] 徐佳兰 李文霞[1] 余英剑[2] 

机构地区：[1]广东省深圳市龙岗区人民医院药剂科,518172 [2]深圳市龙岗中心医院

出　　处：《中国现代药物应用》2017年第6期189-191,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究水合氯醛透皮贴剂的药物动力学和生物利用度。方法以口服10%水合氯醛溶液为对照,采用回滴定法测定20只家兔使用水合氯醛透皮贴剂(贴剂组,10只)和口服溶液(口服组,10只)在相同给药浓度下的血药浓度,采用相关软件处理数据,进行药物动力学和生物利用度的分析。结果贴剂组诱导时间(12.24±3.90)min和维持时间(300.27±30.69)min均长于口服组(8.56±2.12)、(58.81±10.15)min,差异有统计学意义(P<0.05)。贴剂组AUC0^+∞(292.10±89.56)ng/ml·h明显高于口服组(105.42±78.29)ng/ml·h,差异有统计学意义(P<0.01)。贴剂组相对生物利用度是口服组的2.77倍。结论水合氯醛透皮贴剂与口服溶液相比,诱导时间长,维持时间长,且具有不良反应少、生物利用度高的特点。Objective To research pharmacokinetics and bioavailability in chloral hydrate transdermal patch.Methods The control group received oral administration of10%chloral hydrate solution.Back titration method was applied to detected blood drug concentrations in20domestic rabbits receiving chloral hydrate transdermal patch(patch group,10rabbits)and oral solution(oral group,10rabbits)with the same administration concentration.Data were processed by related software for analysis of pharmacokinetics and bioavailability.Results The patch group had both longer induction time as(12.24±3.90)min and maintenance time as(300.27±30.69)min than(8.56±2.12)and(58.81±10.15)min in the oral group,and their difference had statistical significance(P<0.05).The patch group had obviously higher AUC0-+∞as(292.10±89.56)ng/ml·h than(105.42±78.29)ng/ml·h in the oral group,and the difference had statistical significance(P<0.01).The patch group had2.77times relative bioavailability as much as that in the oral group.Conclusion Comparing with oral solution,chloral hydrate transdermal patch shows longer induction time and maintenance time.It containsa dvantages of few adverse reactions and high bioavailability.

关 键 词：水合氯醛 透皮贴剂 口服溶液 药物动力学 生物利用度 

分 类 号：R965[医药卫生—药理学]