粪菌移植治疗幼儿严重食物过敏性胃肠病1例并文献复习  

Fecal bacteria transplantation for treatment of severe gastrointestinal disease caused by food allergy in children: a case report and literature review

作　　者：朱忠生[1] 郑跃杰[1] 蔡华波[1] 白大明[1] 代东伶[1] 周建利[1] 周少明[1] ZHU Zhongsheng;ZHENG Yuejie;CAI Huabo;BAI Daming;DAI Dongling;ZHOU Jianli;ZHOU Shaoming(Shenzhen Children’s Hospital, Shenzhen 518026, Guangdong, China)

机构地区：[1]深圳市儿童医院,广东深圳518026

出　　处：《临床儿科杂志》2017年第4期247-252,共6页Journal of Clinical Pediatrics

基　　金：深圳市卫生计生系统科研项目(No.201507028)

摘　　要：目的探讨严重食物过敏性胃肠病患儿的粪菌移植治疗。方法回顾1例严重食物过敏性胃肠病患儿的粪菌移植治疗过程,并复习相关文献。结果患儿,男,2岁,以肠道感染起病,予以足疗程抗感染及对症支持治疗,腹泻仍迁延不愈,最终给予粪菌移植治疗后,好转出院,随访2个月未见不良反应。检索国外文献,儿童粪菌移植主要应用于难辨梭状芽孢杆菌感染(CDI)和炎症性肠病(IBD)中,有效率分别为90%~100%和55.6%~100%;而国内文献中,粪菌移植在儿童中主要用于CDI和抗生素相关性腹泻病中,有效率100%,均未见严重不良反应。结论粪菌移植治疗儿童严重食物过敏性胃肠病短期安全有效,但其在儿童中的应用技术还不成熟,需要更多、更深入的研究。Objective To explore fecal bacteria transplantation for the treatment of severe gastrointestinal diseasecaused by food allergy.Method The therapeutic process of fecal bacteria transplantation for treatment of severe food allergygastrointestinal disease was retrospectively analyzed,and the related literature was reviewed.Results A2-year-old boyhad onset of intestinal infection and diarrhea was persistent even though he had received adequate anti-infection therapy andsupportive treatment.Finally,the patient received the treatment of fecal bacteria transplantation and the symptoms were thenimproved.No adverse reactions were observed in2months of follow-up.In foreign literature,fecal bacteria transplantation inchildren is mainly applied to clostridium difficile infection(CDI)and inflammatory bowel disease(IBD),with efficiency of90%-100%and55.6%-100%,respectively.While in the domestic literature,fecal bacteria transplantation in children is mainlyused in CDI and antibiotic associated diarrhea,and the effective rate is100%.No serious adverse reactions were found in allthe researches.Conclusion Fecal transplantation is safe and effective in the treatment of children with severe gastrointestinaldisease caused by food allergy,but its application in children is not yet mature and needs more in-depth researches.

关 键 词：食物过敏性胃肠病 粪菌移植 治疗 儿童 

分 类 号：R725.7[医药卫生—儿科]