天癸散敷脐干预围绝经期妇女骨量减少51例  

Treating 51 cases of osteopenia in perimenopause women with Tian'gui on umbilicus

作　　者：林晓生 王海燕[2] 肖庆华 刘汉娇[2] 王健[2] 

机构地区：[1]深圳市宝安区沙井人民医院,广东深圳518104 [2]深圳市宝安区中医院,广东深圳518000

出　　处：《中医临床研究》2017年第5期1-4,共4页Clinical Journal Of Chinese Medicine

基　　金：2013年广东省自然科学基金;编号为s2013010012989;2012年深圳市科技计划项目(医疗卫生类)重点项目;编号为201201019~~

摘　　要：目的:本研究以天癸散敷脐对围绝经期妇女的骨量减少进行干预,观察其临床疗效。方法:将101例骨量减少的围绝经期妇女随机分为两组,干预组51例,对照组50例,两组受试对象均给予基础治疗,干预组给予天癸散敷脐,对照组给予安慰剂(凡士林)敷脐,观察治疗前后骨密度(BMD)、骨源性碱性磷酸酶(BALP)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)以及转化生长因子-β(TGF-β1)等指标,疗程为6个月。结果:干预组能明显降低患者BALP和TRACP-5b含量(P<0.001),提高腰椎骨密度T值和TGF-β1水平(P<0.001);与对照组比较骨密度T值(P<0.05),BALP含量(P<0.01),TRACP-5b和TGF-β1水平的差异均有统计学意义(P<0.001)。结论:天癸散敷脐能显著改善围绝经期骨量减少妇女有关骨代谢指标、骨密度T值以及TGF-β1。Objective:To observe the effects of Tian’gui San on perimenopause women with osteopenia.Methods:101perimenopause women with osteopenia were randomized into a treatment group of51cases and a control group of50cases.The treatment group was intervened by umbilicus application with Tian’gui San;while the control group was treated by umbilicus application with Placebo(Vaseline).After treatment,the therapeutic efficacy was evaluated based on bone density T value,bone metabolic indicators and TGF-β1.Results:In6months,the bone metabolic indicators were reduced very significantly(P<0.001)and the bone density T value of lumbar and TGF-β1were increased very significantly(P<0.001)in the treatment group.The differences between groups have statistical significance,P<0.05,P<0.01,P<0.001.Conclusion:Umbilicus application with Tian'gui San is effective on perimenopause women with osteopenia.

关 键 词：围绝经期 骨量减少 敷脐治疗 治未病 骨密度 骨源性碱性磷酸酶 抗酒石酸酸性磷酸酶 转化生长因子-β1 

分 类 号：R271.116[医药卫生—中医妇科学]