左乙拉西坦添加治疗老年癫痫患者的临床观察  

Clinical Observation of Levetiracetam Add-on Therapy in the Treatment of Elderly Epileptic Patients

作　　者：万令 雷华[2] WAN Ling;LEI Hua(Dept. of Encephalopathy,Chongqing Yunyang County Hospital of TCM,Chongqing404500,China;Dept. of Neurology,Chongqing Fuling Central Hospital,Chongqing 408000,China)

机构地区：[1]重庆市云阳县中医院脑病科,重庆404500 [2]重庆市涪陵中心医院神经内科,重庆408000

出　　处：《中国药房》2017年第11期1516-1518,共3页China Pharmacy

摘　　要：目的:考察左乙拉西坦添加治疗老年癫痫患者的临床效果及安全性。方法:将2014年1月-2016年1月于重庆市云阳县中医院就诊的老年癫痫患者88例按照随机数字表法分为观察组与对照组,各44例。对照组患者给予卡马西平+苯巴比妥常规抗癫痫治疗;观察组患者在对照组基础上加用左乙拉西坦片,初始剂量0.25g,后期根据患者病情可增至0.5g,bid。两组疗程均为6个月。观察两组患者的临床疗效、格拉斯哥昏迷评分法(GCS)评分、巴塞尔(Barthel)指数评分、蒙特利尔认知评估量表(Mo CA)评分和不良反应发生情况。结果:观察组患者的总有效率、控制率和Mo CA评分均显著高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后的GCS和Barthel指数评分均明显高于治疗前,且观察组患者的2项评分均明显高于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:采用左乙拉西坦添加治疗老年癫痫的疗效优于常规治疗方案,使患者的昏迷程度显著降低,日常生活能力与认知功能显著提高,且安全性较好。OBJECTIVE:To investigate clinical efficacy and safety of levetiracetam add-on therapy in the treatment of elderly epileptic patients.METHODS:Totally88elderly epileptic patients in Chongqing Yunyang County Hospital of TCM during Jan.2014-Jan.2016were divided into observation group and control group according to random number table,with44cases in each group.Control group was given routine antiepileptic therapy of carbamazepine+phenobarbital;observation group was additionally given Levetiracetam tablet with initial dose of0.25g,increasing to0.5g according to disease condition,bid,on the basis of control group.Treatment courses of2groups lasted for6months.Clinical efficacies,GCS score,Barthel index score,MoCA scoreand the occurrence of ADR were observed in2groups.RESULTS:Total response rate,control rate and MoCA score of observationgroup were significantly higher than those of control group,with statistical significance(P<0.05).GCS and Barthel index score of2group after treatment were significantly higher than before treatment,and those2scores of observation group were significantly higher than those of control group,with statistical significance(P<0.05).No obvious ADR was found in2groups.CONCLUSIONS:Levetiracetam add-on therapy is better than routine therapy plan in the treatment of elderly epilepsy,and significantly reduce coma degree,increase daily living ability and cognitive function with good safety.

关 键 词：左乙拉西坦 老年患者 癫痫 昏迷 日常生活能力 认知功能 

分 类 号：R971.6[医药卫生—药品] R742.1[医药卫生—药学]