老年患者应用异帕米星联合头孢他啶治疗的有效性及安全性评价  

Efficacy and safety evaluation of isepamicin combined with ceftazidime in the treatment of patients with advanced age

作　　者：汤怡然 唐敏 TANG Yi-ran;TANG Min(Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University, Chongqing 400000, China)

机构地区：[1]第三军医大学第一附属医院药剂科,重庆400000

出　　处：《中国药物应用与监测》2017年第2期69-71,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:评价老年患者使用异帕米星联合头孢他啶抗感染治疗的疗效和安全性。方法:采用回顾性方法,收集2014–2015年我院住院患者中联合使用异帕米星和头孢他啶抗感染治疗的老年患者的临床资料。给药方法为:头孢他啶2~3 g,bid,ivgtt;异帕米星400 mg,qd,ivgtt。主要分析指标为临床有效率、病原菌清除率、治疗前后外周血常规和肾功能。结果:共纳入58例患者,平均年龄67.4岁,患者以大肠埃希菌感染为主,疗程5~17 d。临床有效率为86.2%(50/58),细菌清除率为82.4%(14/17);白细胞计数和中性粒细胞百分比治疗前后有统计学意义(P<0.05)。血肌酐、估算肾小球滤过率及血尿素氮治疗前后差异无统计学意义(P>0.05)。结论:异帕米星联合头孢他啶在老年患者抗感染治疗过程中能有效控制感染,且在严格掌握用药指征、用法、用量、疗程及定期监测下,一般不会引起肾功能损害。Objective:To evaluate the efficacy and safety of isepamicin combined with ceftazidime in anti-infectious treatment of patients with advanced age.Methods:From2014to2015,the clinical data of anti-infectious treatment with isepamicin and ceftazidime in the patients with advanced age in our hospital were collected and analyzed by retrospective method.Intravenous infusion of ceftazidime2–3g twice daily was given.Intravenous infusion of isepamicin400mg once daily was given.The treatment course was5–17days.The major indexes were effective rate,pathogens clearance rate,peripheral white blood cell count(the proportion of neutrophils)before and after the treatment and renal function.Results:A total of58patients were collected with average of67.4years old.The main pathogens in patients were Escherichia coli.The treatment course was5–17days.Theeffective rate was86.2%(50/58),bacterial clearance rate was82.4%(14/17).There were significant differences before and after thetreatment in the levels of the peripheral white blood cell count and the proportion of neutrophils(P<0.05).There were no significant differences before and after the treatment in the levels of serum creatinine,estimated glomerular filtration rate or blood urea nitrogen(P>0.05).Conclusion:Isepamicin combined with ceftazidime for anti-infectious treatment in elderly patients is effective.And this treatment generally dosen't cause renal damage under strict control of drug indications,dosage,administration,treatment course and regular monitoring.

关 键 词：老年患者 异帕米星 头孢他啶 抗感染治疗 肾功能 

分 类 号：R969.4[医药卫生—药理学] R978.1[医药卫生—药学]