3-70 Capsazepine, a TRPV1 Antagonist, Enhances Radiation Sensitivity in Human Hepatocellular Carcinoma HepG2 Cells  

作　　者：Han Lu Di Cuixia Zhang Hong 

机构地区：[1]不详

出　　处：《IMP & HIRFL Annual Report》2014年第1期162-163,共2页中国科学院近代物理研究所和兰州重离子研究装置年报（英文版）

基　　金：Key Program of National Natural Science Foundation of China (U1432248), National Natural Science Foundationof China (11175222, 11205219) , Western Talent Program of Chinese Academy of Sciences (Y260230XB0).

摘　　要：Transient receptor potential vanilloid 1(TRPVl) that is known as capsaicin receptor is a non-selective cationion channel[1]. TRPV1 can regulate Ca2+ influx, participate in a variety of physiological and pathological processof tumor[2]. One such agent is Capsazepine (CPZ) that is now widely used as a selective vanilloid type 1 receptor(TRPV1) antagonist. CPZ can be directly actived on the capsaicin receptor, blocked its biological effects, and abolishedosteosarcoma-induced hyperalgesia when administered subcutaneously at doses ranging from 3 to 10 mg/kg,blocked calcium channels[3]. However, the mechanisms underlying the anticancer effects of CPZ have not fully beenunderstood. Whether CPZ can induce apoptosis of human hepatocellular carcinoma cell line HepG2 is not known.Therefore, the objective of the study reported here was to determine whether CPZ can enhance radiation sensitivityin HepG2 cell, and impact on cell proliferation.

关 键 词：TRPV1 Enhances RADIATION 

分 类 号：O4[理学—物理]