羊膜上皮细胞旁分泌特点及其在皮肤损伤修复中的作用  

The paracrine effect of human amniotic epithelial cells and their roles in wound healing

作　　者：付寅生 张怡 张婷婷 芦慧颖 孟庆雪 Fu Yinsheng;Zhang Yi;Zhang Tingting;Lu Huiying;Meng Qingxue(National and local joint stem cell research & engineering center for aging diseases, Harbin 150028, China;Heilongjiang Tian Qing Stem Cell Co., Ltd, Harbin 150028, China;Harbin First Bio-Engineering Co., Ltd, Harbin 150431, China)

机构地区：[1]黑龙江天晴干细胞股份有限公司,哈尔滨150028 [2]哈尔滨富尔斯特生物工程有限责任公司,哈尔滨150431 [3]老年性疾病干细胞技术国家地方联合工程技术研究中心,哈尔滨150028

出　　处：《中国组织化学与细胞化学杂志》2017年第2期183-190,共8页Chinese Journal of Histochemistry and Cytochemistry

基　　金：黑龙江省自然科学基金项目(C201430)

摘　　要：皮肤损伤修复是一个复杂而又高度协同的生物学过程,多种生长因子及白介素、趋化因子等细胞因子参与该过程,并调控皮肤愈合过程中创面的再上皮化、新血管生成以及细胞外基质沉积与重塑3个重要环节。人羊膜上皮细胞是一种类胚胎干细胞,广泛应用于创面损伤修复研究中。许多研究表明,人羊膜上皮细胞能够通过旁分泌作用促进皮肤创面的愈合。这些旁分泌因子不仅能够抑制创面微环境中细胞的凋亡,还能促进新血管生成和上皮再生。在此,本文综述人羊膜上皮细胞旁分泌特点,探讨人羊膜上皮细胞来源的旁分泌因子在创面愈合中的作用机制,并针对人羊膜上皮细胞或人羊膜上皮细胞来源细胞因子溶液应用于皮肤损伤治疗的未来可行性进行详细阐述。Human skin wound healing is a complex and highly coordinated biological process in which growth factors,interleukins and chemokines play a part and regulate three critical steps namely re-epithelialization,neoangiogenesis,and extracellular matrix(ECM)deposition and remodeling.As primitive stem cells,human amniotic epithelial cells(hAECs)are widely applied in wound healing research.Recent evidence reveals that hAECs facilitate wound healing by secreting soluble bioactive factors via paracrine to protect recipient cells from apoptosis,stimulate neovascularization and promote re-epithelialization.This review will focus on the secretory profiles of hAECs and their roles in wound healing.The therapeutic potential of hAECs or hAECs-derived cytokine solution in wound healing is also discussed.

关 键 词：羊膜上皮细胞 细胞因子 旁分泌 创面修复 

分 类 号：R458[医药卫生—治疗学]