华法林低强度抗凝治疗高龄非瓣膜病性心房颤动长期随访研究  

A long-term follow-up on treatment of senile non-valvular atrial fibrillation with low-intensive warfarin anticoagulation therapy

作　　者：武云涛 陈艳梅 田国祥 姚璐 刘立新 夏常泉 张峰 李响 张薇 高迎春 WU Yun-tao;CHEN Yan-mei;TIAN Guo-xiang;YAO Lu;LIU Li-xin;XIA Changquan;ZHANG Feng;LI Xiang;ZHANG Wei;GAO Ying-chun

机构地区：[1]陆军总医院干四科,北京100700 [2]内蒙古自治区人民医院心血管内科,呼和浩特010017

出　　处：《中国循证心血管医学杂志》2017年第4期430-432,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：军队保健专项课题(15BJZ03);内蒙古自治区科技厅基金(20110501)

摘　　要：目的观察长期应用华法林低强度抗凝治疗高龄非瓣膜病性心房颤动(NVAF)患者的疗效及安全性。方法入选2007年1月~2009年6月期间于陆军总医院治疗的NVAF患者115例,其中男性93例,女性22例。所有患者依据年龄分为高龄老年组(58例,≥80岁)和老年组(57例,65~79岁)。所有患者用药前查血常规、肝肾功能、凝血功能、国际标准化比值(INR)等,均口服华法林,初始剂量为2.5mg/d,采用低强度抗凝,目标INR l.6~2.5,依据INR调整华法林剂量。随访5年,记录达到目标INR的华法林用量和药物的不良反应情况。结果连续监测5年,两组患者达到目标INR稳态的华法林用量比较,差异无统计学意义(P>0.05)。两组INR比较,差异无统计学意义(P>0.05)。所有患者均无急性脑梗死发生。两组不良反应发生率比较(17.2%vs.12.3%),差异无统计学意义(P>0.05)。结论严密监测国际标准化比值下,高龄老年NVAF患者应用华法林抗凝治疗,国际标准化比值控制在1.6~2.5是安全有效的。Objective To observe the curative effect and safety of low-intensive warfarin anticoagulation therapy for a long time in elderly patients with non-valvular atrial fibrillation(NVAF).Methods NVAF patients(n=115,male93and female22)were chosen from the Chinese PLA Army General Hospital from Jan.2007to Jun.2009.All patients were divided,according to age,into very elderly group(n=58,age≥80)and elderly group(n=57,aged from65to79).The patients were given the examinations of blood routine,liver and kidney functions,thrombin function and international normalized ratio(INR),and oral warfarin in predose(2.5mg/d)for low-intensive anticoagulation.The target was that INR was from l.6to2.5and dose of warfarin was regulated according to doses of warfarin.The dose of warfarin accorded with target INR steady and adverse reactions were recorded after followup for5y.Results After continuous monitoring for5y,the difference in doses of warfarin accorded with target INR steady had no statistical significance between2groups(P>0.05).The difference in INR had no statistical significance between2groups(P>0.05).There was no acute cerebral infarction onset in all patients.The difference in incidence of adverse reactions(17.2%vs.12.3%)had no statistical significance between2groups(P>0.05).Conclusion When INR is comprehensively monitored and controlled from1.6to2.5,warfarin is safe and effective for anticoagulation in elderly patients with NVAF.

关 键 词：非瓣膜性心房颤动 华法林 国际标准化比值 安全性 长期随访 

分 类 号：R541.75[医药卫生—心血管疾病]