基于数据挖掘的植物类中药寒热药性-功效-靶点关联性研究  

Correlation Study on “Cold or Heat Property-Efficacy-Target” of Herbal Chinese Materia Medica Based on Data Mining

作　　者：肖雨函 王乃智 张静雯[1] 曹金花[1] 王凤祥[1] 崔双玮 付先军[1] XIAO Yu-han;WANG Nai-zhi;ZHANG Jing-wen;CAO Jin-hua;WANG Feng-xiang;CUI Shuang-wei;FU Xian-jun(School of Information Management, Shandong University of TCM, Jinan 250355, China)

机构地区：[1]山东中医药大学信息管理学院,山东济南250355

出　　处：《中国中医药信息杂志》2017年第6期91-96,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81473369);教育部高等学校博士学科点专项科研基金(20123731120001);山东省人力资源和社会保障厅博士后创新项目(201102036);山东中医药大学大学生研究训练计划(201310441107)

摘　　要：目的探讨植物类中药药性、功效和靶点之间的关联性,分析中药寒热药性效应的分子机制,为诠释中药药性的微观作用机制和科学内涵提供基础。方法整理2015年版《中华人民共和国药典》中关于单味药药性与功效的记载,并参考《药理学研究的新思路与新靶点》及《药理学》,选取509种植物类中药。计算机检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)中记载植物类中药药性、功效、药理作用和靶点的相关文献。筛选靶点信息并进行标准化处理,采用My SQL5.7.13构建数据库,运用R软件平台3.3.1中频数分析及关联规则算法,研究植物类中药药性与功效、靶点的关联性。结果 509种植物类中药中,寒性中药227种,平性中药106种,热性中药176种。数据挖掘结果表明,与寒性关联紧密的功效为止渴、清肝、通淋等,靶点为转化生长因子-β2、肝微粒体酶等;与热性关联紧密的功效为温中、散寒、散痞等,靶点为骨形态蛋白-2、类风湿因子等;与平性关联紧密的功效为敛肺、消胀、益精等,靶点为β-淀粉样蛋白、前列腺素E2受体等。结论中药药性、功效和靶点三者之间存在一定的关联性。Objective To study the correlation among property,efficacy and target of herbal Chinese materiamedica;To analyze the molecular mechanism of cold and heat property of Chinese materia medica;To providereferences for explaination of microcosmic mechanism and scientific connotation of property of Chinese materia medica.Methods Recordings about property and efficacy of single medicine in2015edition of Pharmacopoeia of the People'sRepublic of China were sorted out.According to Pharmacological Research of New Ideas and New Targets andPharmacology,509kinds of herbal Chinese materia medica were selected.Relevant articles about property,efficacy,pharmacologic action,and target in CNKI and Chinese Academic Journal Database(Wanfang Data)were searched bycomputers.The target information was screened and standardized,and the database was constructed by usingMySQL5.7.13.The correlation between the property,efficacy and the target of the herbal Chinese materia medica wasstudied by using the frequency analysis and correlation rule algorithm of R software platform3.3.1.Results509kinds ofherbal Chinese materia medica were selected,including227kinds of cold-property medicine,106kinds ofneutural-property medicine and176kinds of hot-property medicine.According to the result of data mining,efficacy ofcold-roperty medicine was quenching thirst,clearing liver and treating stranguriaetc.The target was transforming growth factorβ2and liver microsome,etc.The efficacy of hot-property medicine was warming the middle,releasing cold anddissolving lumps.The target was bone morphology protein2,rheumatoid factor,etc.The efficacy of neutural-propertymedicine was clearing lungs,diminishing distension and increasing energy.The target wasβ-amyloid and prostaglandinE2receptors.Conclusion There is certain correlation in property,efficacy and target in Chinese materia medica.

关 键 词：植物类中药 药性 功效 靶点 关联性 数据挖掘 

分 类 号：R2-05[医药卫生—中医学] R285.1