盐酸利托君联合硝苯地平治疗晚期先兆流产的临床效果分析  

Analysis of clinical effect by ritodrine hydrochloride combined with nifedipine in the treatment of late-term threatened abortion

作　　者：韩利红[1] 罗太珍[1] 杨帅[1] HAN Li-hong;LUO Tai-zhen;YANG Shuai(Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China)

机构地区：[1]广州医科大学附属第三医院,510150

出　　处：《中国现代药物应用》2017年第9期92-93,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨盐酸利托君联合硝苯地平治疗晚期先兆流产的临床效果。方法 120例晚期先兆流产孕妇作为研究对象,采取数字表法随机分为对照组与观察组,各60例。对照组给予静脉滴注硫酸镁,观察组给予静脉滴注盐酸利托君联合口服硝苯地平片,比较两组临床疗效。结果观察组住院时间(5.24±1.61)d、保胎成功率95.00%、妊娠延长时间(12.23±5.59)周均明显优于对照组(7.32±2.71)d、78.33%、(9.42±3.31)周,差异具有统计学意义(P<0.05);孕妇不良反应表现为胸闷、心率过快、血压下降、心悸等,两组不良反应发生率、新生儿异常发生率比较差异无统计学意义(P>0.05)。结论盐酸利托君联合硝苯地平治疗晚期先兆流产能够有效提高治疗效果,在延长孕妇妊娠时间以及提高妊娠成功率的同时,不会造成胎儿异常及孕妇不良反应发生率增加,因此具有较好的临床推广价值。Objective To investigate clinical effect by ritodrine hydrochloride combined with nifedipinein the treatment of late-term threatened abortion.Methods A total of120pregnant women with late-termthreatened abortion as study subjects were divided by random number table into control group and observationgroup,with60cases in each group.The control group received intravenous drip of magnesium sulfate,theobservation group received intravenous drip of ritodrine hydrochloride combined with oral administration ofnifedipine tablets.Clinical effects were compared between the two groups.Results The observation group hadhospital stay time as(5.24±1.61)d,success rate of fetus protection as95.00%,and prolonged pregnancy time as(12.23±5.59)weeks,which were all better than(7.32±2.71)d,78.33%and(9.42±3.31)weeks in the controlgroup.Their difference had statistical significance(P<0.05).Adverse reactions in pregnant women includedchest distress,high heart rate,blood pressure reduction and palpitation.There was no statistically significantdifference of incidence of adverse reactions and neonatal disorder between the two groups(P>0.05).ConclusionCombination of ritodrine hydrochloride and nifedipine can effectively improve curative effect in treating latetermthreatened abortion.It can prolong pregnancy time and improve pregnancy success rate,without increasedincidence of neonatal disorder and adverse reactions in pregnant women.Therefore,this method contains excellentvalue for clinical promotion.

关 键 词：盐酸利托君 硝苯地平 晚期先兆流产 临床疗效 

分 类 号：R714.21[医药卫生—妇产科学]