儿童化脓性脑膜炎病原菌分布及其耐药性分析  

Pathogenic bacteria distribution and drug resistance of children with purulent meningitis

作　　者：胡伟[1] 王秉圆 李继安[1] 任倩[1] 徐道彦[1] 王世富[1] 聂秀真[1] 林爱伟[1] HU Wei;WANG Bingyuan;LI Jian;REN Qian;XU Daoyan;Wang Shifu;NIE Xiuzhen;LIN Aiwei(Children's Hospital of Jinan, Jinan 250022, Shandong, China;Department of Pediatrics, Maternal and Child Health Care Hospital of Jinan, Jinan 250001,Shandong, China)

机构地区：[1]济南市儿童医院,山东济南250022 [2]济南市妇幼保健院儿科,山东济南250001

出　　处：《临床儿科杂志》2017年第5期366-368,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨儿童化脓性脑膜炎病原菌分布及其对抗菌药物的敏感性。方法回顾分析2010年1月-2014年12月收治的54例化脓性脑膜炎患儿的脑脊液涂片及培养结果。结果 54株病原菌以革兰阳性球菌为主共36株,革兰阴性杆菌17株,疑似脑膜炎奈瑟菌1例。革兰阳性球菌中以肺炎链球菌为主共31株,革兰阴性杆菌中以大肠埃希菌为主。革兰阳性球菌中61.3%对青霉素敏感,90%以上对头孢曲松、头孢吡肟敏感,对美洛培南敏感率83.3%,对阿奇霉素耐药达94.7%,18株对苯唑西林耐药58.1%;在革兰阴性杆菌中,对氨苄西林舒巴坦敏感率60%,对头孢他啶敏感率71.4%,对头孢曲松敏感率57.1%,对头孢吡肟敏感率66.6%。结论济南地区儿童化脓性脑膜炎病原菌以肺炎链球菌和大肠埃希菌为主。Objective To explore pathogenic bacteria distribution and drug susceptibility testing results in children withpurulent meningitis in Jinan area.Methods A total of54children with purulent meningitis were selected from January2010toDecember2014,the cerebrospinal fluid smear and culture,according to the national standard of clinical inspection technologyfor bacteria isolation and identification by disc diffusion method for drug sensitive test were retrospectively analyzed.Results A total of54strains of pathogenic bacteria including36strains of gram-positive coccus,and17strains of gram-negative bacillusand one strain of suspected Neisseria meningitides were found.A total of31strains gram positive coccus is Streptococcuspneumoniae,and most gram-negative bacilli is E.coli.In the Gram-positive coccus,61.3%was sensitive to penicillin,and morethan90%was sensitive to ceftriaxone and cefepime,83.3%was sensitive to meropenem,94.7%resistant to azithromycin,and58.1%resistant to oxazocilline.In Gram-negative bacilli,60%was sensitive to ampicillin sulbactam71.4%was sensitive tocephalosporin,57.1%was sensitive to ceftriaxone,66.6%was sensitive to cefepime.Conclusions From cerebrospinal fluidcultured of purulent meningitis,Streptococcus pneumoniae and E.coli were major pathogenic bacteria in children with purulentmeningitis in Jinan area.

关 键 词：化脓性脑膜炎 病原菌 药敏试验 

分 类 号：R446.5[医药卫生—诊断学] R742.9[医药卫生—临床医学]