骨质疏松症的临床研究进展  

Progress of Diagnosis and Treatment of Osteoporosis

作　　者：姜彩云[1] 吴祝峰 罗宇燕[1] 郭喆霏[1] 张永明[1] JIANG Caiyun;WU Zhufeng;LUO Yuyan;GUO Zhefei;ZHANG Yongming(Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China;Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China)

机构地区：[1]中山大学附属第三医院药剂科,广东广州510630 [2]暨南大学附属第一医院药剂科,广东广州510630

出　　处：《清远职业技术学院学报》2017年第3期45-49,共5页Journal of Qingyuan Polytechnic

基　　金：广东省医院药学研究基金资助项目(2015SW12)

摘　　要：目的介绍骨质疏松(osteoporosis,OP)的常见病因、诊断标准和治疗药物的研究进展,为今后的深入研究提供一个参考。方法进行深入分析并总结近年来的相关文献。结果 OP的发病原因比较复杂,主要是由于年龄增长、性激素分泌减少、某些疾病或者药物等诱因导致的;目前还没有一个直接测量及评估骨强度的理想方法,骨密度(bone mineral density,BMD)测量被作为临床上诊断OP常用的定量指标;防治OP的药物主要有骨吸收抑制剂、骨形成促进剂、骨矿化剂和一些滋阴补肾的中药等,骨吸收抑制剂通过促进骨形成和抑制破骨细胞(osteoclast,OC)活性削弱其对骨吸收的速度从而提高BMD、增强骨强度,骨形成促进剂则是直接促进骨形成提高BMD。结论雌激素减少、器官及其生理功能随着年龄增长而衰退等是OP发生的主要原因;已经发生脆性骨折或BMD低下是临床上诊断OP的通用指标;目前,临床上防治OP的相关药物还是以骨吸收抑制剂为主,其中双磷酸盐(bisphosphonates,BP)是较为常用的骨吸收抑制剂。Objective:To introduce the common etiology,standard of diagnosis and drugs of osteoporosis as a reference forfurther study.Methods:Analyze and summarize the related articles in recent years.Results:The etiologies which caused OPmainly contain increase of age,reduce of sex hormone,diseases or drugs and so on;The direct measurement or evaluation methodof bone strength is not built until now,bone mineral density measurement was used as a standard of diagnosis of osteoporosis;Bone resorption inhibitor,bone formation promoter,bone mineralizing agent and traditional Chinese medicine are the main drugsto prevent and control OP,bone resorption inhibitor improve the BMD and bone strength via inhibiting the activity of osteoclastwith allowing bone formation,Bone formation promoter can improve the BMD just via stimulating bone formation.Conclusion:Themainly reasons that lead to OP contain estrogen deficiency,organ recession and physiological function recession;the general indexin the diagnosis of OP in clinical include fracture and low BMD;Bisphosphonates which falls into the category of bone resorptioninhibitor is the main drug for osteoporosis.

关 键 词：骨质疏松 病因 诊断标准 骨吸收抑制剂 骨形成促进剂 

分 类 号：R259[医药卫生—中西医结合]