新生儿乙肝疫苗接种对乙肝病毒表面抗原阳性率的影响  

Effect of hepatitis B vaccine on the positive rate of hepatitis B virus surface antigen in newborns

作　　者：张丽[1] 陈波[1] Li ZHANG;Bo CHEN(Department of Pediatrics, The First Affiliated Hospital of Shihezi University Medical College, Shihezi 832000, China)

机构地区：[1]石河子大学医学院第一附属医院儿科,石河子832000

出　　处：《临床检验杂志（电子版）》2016年第4期202-204,共3页Clinical Laboratory Journal(Electronic Edition)

摘　　要：目的分析新生儿乙肝疫苗接种对乙肝病毒表面抗原(hepatitis B virus surface antigen,HBs Ag)阳性率的影响。方法选取2014年6月-2015年10月期间我院收治的140例1个月内的新生儿,按照采血时新生儿周龄划分为A组(n=100)和B组(n=40),A组为周龄在1周以下,B组为周龄在1周以上至1个月内。采用化学发光(定量分析)和酶联免疫吸附试验(定性分析)对接种乙肝疫苗后血清中的HBs Ag进行检测。对两组结果进行比较。结果A组新生儿的定量阳性率为18%,定性阳性率为6%;B组新生儿的定量阳性率为5%,定性阳性率为5%,组间差异均有统计学意义(P<0.05)。结论少数新生儿进行乙肝疫苗接种后其HBs Ag经检查呈现阳性,但这并不是乙肝病毒感染。Objective To analyze the effect of hepatitis B vaccine on the pasitive rate of hepatitis Bvirus surface antigen(HBsAg)in newborns.Methods A total of140neonatal cases within one month in ourhospital from June2014to October2015were selected.In accordance with the age at the time of blood collectionwas divided into A group(n=100)and B group(n=40).A group was less than one week,B group was betweenone week and one month.The serum levels of HBsAg were detected by chemiluminescence(quantitative analysis)and enzyme linked immunosorbent assay(qualitative analysis).The results between the two groups werecompared.Results The quantitative positive rate of group A was18%,the qualitative positive rate was6%;Thequantitative positive rate of group B was5%,the qualitative positive rate was5%.There was significant differencebetween the groups(P<0.05).Conclusion After hepatitis B vaccination,a small number of newborns werepositive for HBsAg,but which is not hepatitis B virus infection.

关 键 词：新生儿 乙肝疫苗 乙肝病毒表面抗原 

分 类 号：R186[医药卫生—流行病学]