纳米低温保护剂在低温生物中应用的研究进展  

Research Progress on Application of Nano-cryoprotectants in Cryobiology

作　　者：宋萍[1] 李维杰[1] 王利红[1] 孙文全[1] 刘宝林[1] SONG Ping;LI Weijie;WANG Lihong;SUN Wenquan;LIU Baolin(School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《制冷技术》2017年第2期14-19,共6页Chinese Journal of Refrigeration Technology

基　　金：国家自然科学基金资助项目(No.51376132);上海市自然科学基金资助项目(No.13ZR1429200);"十二五"国家科技支撑计划项目(No.2013BAD19B01)

摘　　要：为了更好地了解纳米粒子改变低温保护剂溶液性质的机制,并进一步利用纳米技术改进低温保存效果,本文介绍了纳米低温保护剂的兴起、发展历程;论述了在生物低温保存过程中加入纳米低温保护剂可以提高溶液的导热系数,改变流变学特性,增大黏度,降低过冷度以及改变玻璃化性质,归纳总结了纳米低温保护剂在低温生物中的应用以及未来的发展前景。In order to have a better understanding of the mechanism of nanoparticles to change the properties ofcryoprotectants,and to further utilize nanotechnology to improve the effect of cryopreservation,the rise anddevelopment progress of nano-cryoprotectants was introduced.Nanoparticles could promote thermal conductivity,change rheological properties,increase the viscosity,reduce supercooling and alter vitrification properties in theprocess of cryopreservation.It summed up the application of nano-cryoprotectants in cryobiology and theforeground of cryopreservation.

关 键 词：纳米粒子 低温保护剂 导热系数 玻璃化性质 低温保存 

分 类 号：R318.52[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]