盐酸右美托咪定复合芬太尼麻醉对高血压脑出血患者行微创抽吸术中镇静效果及预后的影响  

Effects of Dexmedetomidine Hydrochloride Combined with Fentanyl Anesthesia on Sedation and Prognosis of Patients with Hypertensive Intracerebral Hemorrhage During Minimally Invasive Aspiration

作　　者：王洪明 WANG Hong-ming(Department of Anesthesiology, the First People's Hospital in Luoyang, Luoyang Henan 473000, China)

机构地区：[1]洛阳市第一人民医院麻醉科,河南洛阳473000

出　　处：《药品评价》2017年第9期47-49,共3页Drug Evaluation

摘　　要：目的:探讨盐酸右美托咪定复合芬太尼麻醉对高血压脑出血患者行微创抽吸术中镇静效果及预后的影响。方法:选取2014年1月至2016年2月于洛阳市第一人民医院行微创抽吸术治疗的64例高血压脑出血患者,通过随机数字表法分组,各32例。对照组联合采用丙泊酚及芬太尼实施麻醉,研究组联合采用盐酸右美托咪定及芬太尼实施麻醉。统计对比术中两组镇静效果、不良反应发生率、入院时及6个月后日常生活能力评分(quality of life,QOL)变化情况。结果:研究组镇静良好率(87.50%)高于对照组(62.50%),差异有统计学意义(P<0.05);研究组恶心呕吐率(3.13%)、心动过速率(6.25%)、低血压率(0.00%)、躁动率(9.38%)低于对照组(25.00%、28.12%、21.88%、37.50%),差异有统计学意义(P<0.05);治疗前两组QOL评分比较,差异无统计学意义(P>0.05),术后研究组QOL评分高于对照组,差异有统计学意义(P<0.05)。结论:盐酸右美托咪定复合芬太尼麻醉效果良好,可提高高血压脑出血患者微创抽吸术中镇静效果,改善预后,且安全性较高。Objective:To investigate the effects of dexmedetomidine hydrochloride combined with fentanyl anesthesia on sedation and prognosis in patients with hypertensive intracerebral hemorrhage during minimally invasive aspiration.Methods:From January2014to February2016,64patients with hypertensive intracerebral hemorrhage underwent minimally invasive aspiration in The First People's Hospital in Luoyang were randomly divided into control group and study group,each group with32cases.The control group was given propofol and fentanyl for anesthesia,and the study group was given dexmedetomidine hydrochloride combined with fentanyl for anesthesia.Sedative effect,the incidence of adverse reactions,admission and6months after the daily life ability score(QOL)changes were compared between the two groups.Results:The good rate of sedation of the study group(87.50%)was higher than that of the control group(62.50%),the difference was statistically significant(P<0.05);The rate of nausea and vomiting(3.13%),tachycardia(6.25%),hypotension(0.00%)and restlessness(9.38%)of the study group were lower than those in the control group(25.00%,28.12%,21.88%,37.50%),the difference was statistically significant(P<0.05);There was no significant difference in QOL scores between the two groups before treatment(P>0.05),but after operation,the study group was significantly higher than that of the control group(P<0.05).Conclusion:The anesthesia effect of dexmedetomidine hydrochloride combined with fentanyl is good,can improve the sedative effect of minimally invasive aspiration in patients with hypertensive intracerebral hemorrhage and improve prognosis,with higher safety.

关 键 词：盐酸右美托咪定 芬太尼 高血压脑出血 微创抽吸术 镇静效果 

分 类 号：R614[医药卫生—麻醉学]