我国2006-2015年肠外营养处方中维生素使用的文献分析  

Literature Analysis of Vitamins Utilization in Parenteral Nutrition Prescription in China during 2006-2015

作　　者：陈莲珍[1] 王雨潇 杨谨成[1] 李素敏 刘杰 杨梅[1] 李国辉[1] 于健春[3] CHEN Lianzhen;WANG Yuxiao;YANG Jincheng;LI Sumin;YANG Mei;LI Guohui;YU Jianchun(Dept. of Pharmacy,National Cancer Center/Cancer Hospital of Beijing Union Medical College,Chinese Academy of Medical Sciences,Beijing 100021,China;Beijing Jingwei Xinkang Institute of Materia Medica,Beijing 100089,China;Dept. of General Surgery,Beijing Union Hospital,Beijing 100032,China)

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院药剂科,北京100021 [2]北京京卫信康药物研究所,北京100089 [3]北京协和医院基本外科,北京100032

出　　处：《中国药房》2017年第17期2326-2330,共5页China Pharmacy

基　　金：国家重点研发计划课题(No.2016YFA0201504);卫生计生委行业基金资助项目(No.201502022)

摘　　要：目的:了解我国肠外营养处方中维生素的使用情况,为我国肠外营养中维生素的合理使用提供参考。方法:以"肠外营养"或"静脉营养"和"处方分析"或"合理用药"或"医嘱分析"为关键词,检索中国知网和万方数据库中2006-2015年报道的有关肠外营养处方合理性分析文献,对纳入文献中维生素的使用情况进行分析和总结。结果:共纳入34篇文献,涉及的总处方数为158 874份,其中145 400份(91.52%)处方使用了维生素;有73 508份(46.27%)处方使用了12或13种维生素,53 388份(33.60%)处方被文献作者认为超量使用维生素,18 504份(11.65%)处方维生素添加不完全,1 663份(1.05%)处方未添加维生素。我国北部地区添加12或13种维生素的比例最高(52.00%)。"三甲"医院添加12或13种维生素、文献作者认为超量使用维生素和水溶性维生素、脂溶性维生素均未完全添加的比例均低于"三甲"以下医院。使用12或13种必需维生素比例由高到低的处方科室依次为肿瘤科(97.72%)、内科(86.62%)、重症监护病房(77.99%)和外科(52.83%)。结论:我国肠外营养处方中维生素规范使用的比例偏低,肠外营养中应添加符合推荐的多种维生素的观念仍需加强。OBJECTIVE:To investigate the application of vitamins in parenteral nutrition(PN)prescription,and to providereference for rational use of vitamins in PN.METHODS:Using“parenteral nutrition”“intravenous nutrition”“prescription analysis”“rational drug use”“analysis of medical order”as keywords,the literatures about the rationality analysis of PN prescriptionswere retrieved from CNKI and Wanfang database during2006-2015,and the utilization of vitamin included in literatures were analyzedand summarized.RESULTS:A total of34literatures were included.There were158874prescriptions,among which vitaminwas used in145400prescriptions(91.52%).12or13kinds of vitamin were used in73508prescriptions(46.27%);over-dosedrug use was found in53388prescriptions(33.60%),and vitamin was not completely added into18504prescriptions(11.65%);no vitamin was added into1663prescriptions(1.05%).The proportion of the prescriptions including12or13kinds of vitaminwas the highest in northern China(52.00%).12or13kinds of vitamin were added into the prescriptions and the author believedthat the proportion of excessive use of vitamin,incomplete addition of water-soluble vitamin and fat-soluble vitamin in class threegrade A hospitals were all lower than hospitals below class three grade A.The prescriptions including12or13kinds of necessary vitaminwere adopted in oncology department(97.72%),internal medicine department(86.62%),intensive care unit(77.99%)andsurgery department(52.83%).CONCLUSIONS:The standardized use of vitamin PN prescriptions occupies low proportion in China.It is necessary to enhance the conception that multiple recommended vitamins should be added into PN.

关 键 词：营养支持治疗 肠外营养 维生素 合理用药 处方分析 

分 类 号：R977.2[医药卫生—药品] R969.3[医药卫生—药学]