某院2013—2015年813例ADR报告分析  

Analysis of 813 Cases of ADR Reports in a Hospital during 2013-2015

作　　者：吴迪[1] 王真 WU Di;WANG Zhen(Dept. of Pharmacy,Chongqing Emergency Medical Center,Chongqing 400014,China;Dept. of Pharmacy,Chongqing People’s Hospital,Chongqing 400013,China)

机构地区：[1]重庆市急救医疗中心药剂科,重庆400014 [2]重庆市人民医院药剂科,重庆400013

出　　处：《中国药房》2017年第17期2359-2362,共4页China Pharmacy

摘　　要：目的:了解某三级甲等医院药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:对该院2013-2015年上报至国家ADR监测中心的813例ADR报告,按照患者年龄、性别、给药途径、药品种类、ADR累及器官/系统及临床表现、转归等进行回顾性分析。结果:813例ADR报告中,男性391例(48.09%),女性422例(51.91%);60岁以上的患者为ADR高发人群,有347例(42.68%);以静脉给药途径引发ADR最多,有747例(91.88%);药品种类中抗感染药引起的ADR例数最多,有382例(46.99%),其中头孢菌素类占比最高,为38.22%(146例);ADR累及器官/系统以皮肤及其附件为主,有434例(53.38%)。结论:对于静脉给药、使用抗感染药的老年患者应加强ADR监测,以减少ADR的发生,保证用药安全。OBJECTIVE:To investigate the characteristics and regularity of adverse drug reaction(ADR)in a third gradeclass A hospital,and to provide reference for rational drug use in clinic.METHODS:A total of813cases of ADR reported to NationalADR Monitoring by the hospital during2013-2015were summarized and analyzed retrospectively in terms of age,gender,route of administration,drug type,organs or systems involved in ADR,clinical manifestation and outcome.RESULTS:Among813cases of ADR,there were391male(48.09%)and422female(51.91%).Patients aged more than60were with high incidenceof ADR,involving347cases(42.68%).Among routes of administration,most ADR cases were caused by intravenous administration,involving747cases(91.88%).Among all drug types,the number of ADR cases caused by anti-infective drugs wasthe most,involving382cases(46.99%);cephalosporins took up the highest proportion,being38.22%(146cases).Organs or systemsinvolved in ADR were mainly skin and its appendants,involving434cases(53.38%).CONCLUSIONS:ADR monitoringshould be strengthened for elderly patients receiving anti-infective drugs intravenously so as to reduce the occurrence of ADR andguarantee medication safety.

关 键 词：药品不良反应 用药安全 合理用药 

分 类 号：R969.3[医药卫生—药理学]